Phenotypes of successful living among adolescents with HIV in Rwanda: a latent profile analysis
- PMID: 40410733
- PMCID: PMC12100999
- DOI: 10.1186/s12889-025-23138-9
Phenotypes of successful living among adolescents with HIV in Rwanda: a latent profile analysis
Abstract
Background: HIV remains a major public health concern globally, and 85% of adolescents with HIV (AWH) live in Sub-Saharan Africa (SSA). Despite advances in treatment and prevention efforts, adolescents continue to be disproportionately affected by HIV and are a group with poor adherence to antiretroviral medication. We identified phenotypes of successful living among adolescents with HIV in Rwanda.
Methods: A multi-stage stratified random sampling was used to collect data from 300 AWH using a validated and piloted questionnaire from four provinces and Kigali City in Rwanda. Data were collected in August 2023 and were analyzed using latent profile analysis (LPA). The following variables were computed to measure their associations and determine the latent profiles (or phenotypes) of successful living: viral load, number of sex partners in a lifetime, condom use during sex, adherence to HIV antiretroviral therapy, HIV stigma, depressive symptoms, state of hope, self-esteem, resilience, disclosure, HIV quality of life, and perceived social support.
Results: The two distinct profiles of successful living among adolescents with HIV were identified through LPA: 46% of adolescents struggled to live with HIV (the first profile) while 54% of adolescents lived successfully with HIV (the second profile). There are several factors associated with successful living among AWH. Successful living was positively associated with spirituality, residing with family members, a stable home environment, psychological well-being, social support, and acquiring HIV through vertical transmission. The adherence to ART, HIV-related stigma, levels of depression, hope, self-esteem, resilience, availability of social support, and patterns of disclosure of HIV status are determinants of adolescents' experiences of living with HIV. Additionally, adolescents tend to struggle to live with HIV in late adolescence, especially when the factors associated with successful living are not met.
Conclusions: This study identified two profiles of Successful Living among AWH. Our results suggest developing profile-oriented, tailored interventions to improve the quality of life and health outcomes of AWH.
Keywords: Adolescent; HIV; Latent profile analysis; Phenotypes; Successful living.
© 2025. The Author(s).
Conflict of interest statement
Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board of the University of Rwanda College of Medicine and Health Sciences (N° 047/CMHS IRB/2022), Rwanda National Ethics Committee (No.107/RNEC/2022) and was issued the collaboration by the Rwanda Biomedical Center (Ref. N° 5534/RBC/2022). Participation was voluntary. Participants were explained about the study and given the opportunity to ask questions. Written informed consent was obtained from all participants, with minors providing assent and their parents/guardians giving consent. Those without formal education indicated their consent/assent using thumbprints in place of signatures. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
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References
-
- UNICEF. To ramp up our efforts in the fight against AIDS, there is a need for more concentrated focus on adolescents and young people [Internet]. Adolescent HIV prevention. 2022 [cited 2024 Apr 28]. Available from: https://data.unicef.org/topic/hivaids/adolescents-young-people/#:~:text=...
-
- Okawa S, Mwanza Kabaghe S, Mwiya M, Kikuchi K, Jimba M, Kankasa C et al. Psychological well-being and adherence to antiretroviral therapy among adolescents living with HIV in Zambia. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV [Internet]. 2018;30:634–42. Available from: 10.1080/09540121.2018.1425364 - PubMed
-
- UNAIDS, Global. HIV & AIDS statistics - Fact sheet [Internet]. Ending the Aids Epidermics. 2024. Available from: https://www.unaids.org/en/resources/fact-sheet
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