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Review
. 2025 Aug:209:110950.
doi: 10.1016/j.radonc.2025.110950. Epub 2025 May 22.

Recommendations for radiotherapy quality assurance in clinical trials

Camilla Panduro Nielsen  1 , Eva Samsøe  2 , Birgitte Vrou Offersen  3 , Ebbe Laugaard Lorenzen  1 , Gitte Persson  4 , Hanna Rahbek Mortensen  5 , Henrik Dahl Nissen  6 , Ivan Richter Vogelius  7 , Jesper Folsted Kallehauge  5 , Ludvig Paul Muren  5 , Mads Brincker  8 , Mette van Overeem Felter  9 , Rikke Hedegaard Dahlrot  10 , Steffen Bjerre Hokland  11 , Tine Schytte  12 , Birgitte Mayland Havelund  6 , Britta Weber  13 , Ditte Sloth Møller  11 , Eva Serup-Hansen  9 , Kenneth Jensen  14 , Kirsten Legård Jakobsen  2 , Mirjana Josipovic  7 , Simon Long Krogh  15 , Slávka Lukacova  11 , Lone Hoffmann  11 , Christian Rønn Hansen  16
Affiliations
Free article
Review

Recommendations for radiotherapy quality assurance in clinical trials

Camilla Panduro Nielsen et al. Radiother Oncol. 2025 Aug.
Free article

Abstract

Robust quality assurance (QA) of clinical trials in radiotherapy (RT) is paramount for minimising uncertainties in treatment delivery, thereby strengthening the statistical power of the study and increasing the likelihood of accurately answering the research question. As RT techniques evolve and become more complex, establishing an appropriate QA program for a specific clinical trial becomes increasingly challenging, highlighting the importance of clear and standardised recommendations. This study provide such recommendations for Principal Investigators (PIs) to consider when planning and conducting RT Quality Assurance (RTQA) for clinical trials. They arise from experiences with RTQA in the clinical trials conducted in the Danish Multidisciplinary Cancer Groups (DMCGs). The recommendations include a checklist to guide PIs in developing an effective RTQA program.

Keywords: Clinical trials; Quality assurance; Radiotherapy; Recommendations.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.