Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders

Jurgen Sota¹, Luciana Breda², Maria Pia Paroli³, Soad Hashad^{4

5}, Alejandra de-la-Torre⁶, Silvana Guerriero⁷, Abdurrahman Tufan⁸, Juanita Cardona-López⁶, María José Altamar-García⁶, Saverio La Bella², Antonio Vitale¹, Edoardo Biancalana⁹, Emanuela Del Giudice¹⁰, Francesca Minoia¹¹, Sulaiman Al-Mayouf¹², Bruno Frediani¹, Luca Cantarini¹, Claudia Fabiani¹³

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
² Pediatric Rheumatology Unit, G d'Annunzio University, Chieti, Italy.
³ Department of Sense Organs, Eye Clinic, Uveitis Unit, University La Sapienza, Rome, Italy.
⁴ Department of Rheumatology, Tripoli Children Hospital, Tripoli, Libya.
⁵ Department of Rheumatology Department, University of Tripoli, Tripoli, Libya.
⁶ Neurovitae Center for Neuroscience, Institute of Translational Medicine, Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
⁷ DiBrain Department, University of Bari, Bari, Italy.
⁸ Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Turkey.
⁹ Department of Experimental and Clinical Medicine, Internal Interdisciplinary Medicine Unit, Lupus Clinic, Careggi University Hospital, Florence, Italy.
¹⁰ Department of Maternal Infantile and Urological Sciences, Pediatric and Neonatology Unit, Università degli Studi di Roma La Sapienza, Rome, Italy.
¹¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
¹² Deparment of Pediatrics, King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
¹³ Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy claudia.fabiani@aidanetwork.org.

PMID: 40413020
DOI: 10.1136/bjo-2025-327410

Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders

Jurgen Sota et al. Br J Ophthalmol. 2025.

. 2025 May 24:bjo-2025-327410.

doi: 10.1136/bjo-2025-327410. Online ahead of print.

Authors

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
² Pediatric Rheumatology Unit, G d'Annunzio University, Chieti, Italy.
³ Department of Sense Organs, Eye Clinic, Uveitis Unit, University La Sapienza, Rome, Italy.
⁴ Department of Rheumatology, Tripoli Children Hospital, Tripoli, Libya.
⁵ Department of Rheumatology Department, University of Tripoli, Tripoli, Libya.
⁶ Neurovitae Center for Neuroscience, Institute of Translational Medicine, Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
⁷ DiBrain Department, University of Bari, Bari, Italy.
⁸ Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Turkey.
⁹ Department of Experimental and Clinical Medicine, Internal Interdisciplinary Medicine Unit, Lupus Clinic, Careggi University Hospital, Florence, Italy.
¹⁰ Department of Maternal Infantile and Urological Sciences, Pediatric and Neonatology Unit, Università degli Studi di Roma La Sapienza, Rome, Italy.
¹¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
¹² Deparment of Pediatrics, King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
¹³ Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy claudia.fabiani@aidanetwork.org.

PMID: 40413020
DOI: 10.1136/bjo-2025-327410

Abstract

To describe tocilizumab (TCZ) effectiveness in 15 children with refractory non-infectious uveitis. Reported outcomes are the number of relapses before and after treatment, steroid-sparing effect and drug retention rate. Macular oedema, fluorangiographic findings and ocular complications are also reported.The mean number of ocular relapses significantly decreased from 314 per 100 eyes/year to 106 per 100 eyes/year (p=0.016). A significant steroid-sparing effect was detected (p=0.037). TCZ drug survival was 77.4% at 6 months, followed by 61.9% at 12, 24 and 36 months of follow-up. Macular oedema and retinal vasculitis resolved in all affected eyes.

Keywords: Uveitis.

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Conflict of interest statement

Competing interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders

Affiliations

Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders

Authors

Affiliations

Abstract

Conflict of interest statement

LinkOut - more resources

Full Text Sources