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Review
. 2025 Nov;46(11):644-653.
doi: 10.1016/j.revmed.2025.05.008. Epub 2025 May 23.

[From endemic to pandemic Mpox virus infection]

[Article in French]
Alexandre Robin  1 , Yasmine Abi Aad  1 , Nadia Valin  1 , Romuald Cruchet  1 , Pauline Naudion  1 , Thibault Chiarabini  1 , Quentin Richier  2
Affiliations
Review

[From endemic to pandemic Mpox virus infection]

[Article in French]
Alexandre Robin et al. Rev Med Interne. 2025 Nov.

Abstract

The Mpox virus is an Orthopoxvirus that typically causes benign pustular skin lesions, but can also lead to rare cases of invasive disease. In 2022, clade IIb of this zoonotic virus, endemic to West and Central Africa, spread globally, resulting in 99,176 cases across 116 countries. In 2024, a rapid surge in clade Ib infections in Central Africa, followed by the first European cases - most notably in France on January 6, 2025 - raised concerns about the risk of a new pandemic outbreak. This review article aims to summarize current knowledge on Mpox virus infection, providing insights that may prove valuable in the event of a confirmed pandemic.

Keywords: MPX; MPXV; Monkeypox; Mpox; Orthopoxvirus; Variole du singe.

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Conflict of interest statement

Déclaration de liens d’intérêts Les auteurs déclarent ne pas avoir de liens d’intérêts.

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