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Review
. 2025 May 24;10(1):105.
doi: 10.1038/s41541-025-01145-6.

Comparing Moderna's mRNA-1083 and Pfizer's dual-target mRNA vaccines for influenza and COVID-19

Adewunmi Akingbola  1 , Abiodun Adegbesan  2 , Kolade Adegoke  3 , Courage Idahor  4 , Petra Mariaria  1 , Favour Peters  1 , Raolat Adenike Salami  5 , Olajide Ojo  6 , Emmanuel Nwaeze  7 , Owolabi Abdullahi  8 , Joel Chuku  9
Affiliations
Review

Comparing Moderna's mRNA-1083 and Pfizer's dual-target mRNA vaccines for influenza and COVID-19

Adewunmi Akingbola et al. NPJ Vaccines. .

Abstract

This review examines Moderna's mRNA-1083 and Pfizer/BioNTech's mRNA-1020/1030 dual-target vaccines for COVID-19 and influenza. Both utilize mRNA technology, demonstrating strong immunogenicity and favorable safety profiles. Moderna's mRNA-1083 showed superior immune responses, while Pfizer's mRNA-1020/1030 performed well but was slightly less effective against influenza B. These vaccines simplify immunization strategies, enhance protection, and emphasize the need for global vaccine equity to prevent future outbreaks.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Differences between Moderna’s mRNA-1083 and Pfizer/BioNTech’s mRNA-1020/1030 vaccines.
See this image and copyright information in PMC

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