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. 2025 May 24;25(3):15.
doi: 10.1038/s41397-025-00369-y.

Influence of genetic biomarkers on cardiac diseases in childhood cancer survivors: a systematic review

Naïla Aba  1   2 , Claire Ducos  3   4 , Eric Morel  5 , Chiraz El Fayech  4   6 , Brice Fresneau  3   4   6   7 , Florent de Vathaire  3   4   7 , Gwénaël Le Teuff #  8   9 , Nadia Haddy #  3   4   7
Affiliations

Influence of genetic biomarkers on cardiac diseases in childhood cancer survivors: a systematic review

Naïla Aba et al. Pharmacogenomics J. .

Abstract

Childhood cancer survivors (CCS) often suffer from cardiac disease (CD) after treatment that included anthracycline and radiotherapy involving the heart. However, the variability in CD occurrence cannot be explained solely by these treatments, suggesting the existence of genetic predisposition. We conducted a systematic review searching on Medline-PubMed and Scopus, to identify studies reporting associations between genetic factors and CD in CCS. We included studies published up to 11 April 2023, with no lower limit, and assessed the quality of genetic associations by the Q-genie tool. As a result, 20 studies were included (15 case-control and five cohorts), revealing several genes and variants associated with cardiomyopathy, among which, SLC28A3-rs7853758, RARG-rs2229774, P2RX7-rs208294 and P2RX7-rs3751143 variants gave the most consistent findings. This review highlights the necessity to establish a set of clinically useful genes and variants to identify patients most at risk of developing cardiomyopathy, and to implement monitoring and prevention strategies.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram outlining search strategy and the final included and excluded studies.
See this image and copyright information in PMC

References

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