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. 2025 May 24;15(1):18079.
doi: 10.1038/s41598-025-03523-5.

Fat mass in postmenopausal women with osteoporosis is associated with cognitive function

Dongxue Zhang #  1 , Zijing Zhu #  1 , Lu Xue  1 , Yifeng Zheng  1 , Xiongfeng Li  1 , Miyang Xu  2 , Xinfang Xie #  3 , Yongli Wang #  4
Affiliations

Fat mass in postmenopausal women with osteoporosis is associated with cognitive function

Dongxue Zhang et al. Sci Rep. .

Abstract

Postmenopausal women undergo significant changes in endogenous hormones, which lead to reduced bone mineral density (BMD) and alterations in body composition. However, the relationship between body composition and cognitive function in this demographic has not yet been explored. This study aims to examine this relationship in postmenopausal women with osteoporosis.This survey will involve 120 postmenopausal women with osteoporosis. Dual-energy X-ray absorptiometry (DXA) will be used to assess L1-L4 BMD, fat mass (FM), trunk fat mass (TFM), fat-free mass (FFM), and appendicular skeletal muscle mass (ASMM). The relationship between body composition and cognitive function will be analyzed using t-tests and multiple linear regression.Our findings suggest that in postmenopausal women with osteoporosis, cognitive function (MMSE score) is positively correlated with body composition indicators such as FM and BMD, and positively correlated with educational level, but negatively correlated with age. FM plays a significant role in influencing cognitive function and is a crucial indicator of body composition in postmenopausal women with osteoporosis.

Keywords: Body composition; cognition function; fat mass; fat-free mass; postmenopausal osteoporosis.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Conflict of interest: The authors declare that there are no conflicts of interest. Statement: This study had been approved by the Medical Ethics Committee of Huzhou Central Hospital (No. 202303041-01).And the study was performed in accordance with relevant regulations.And informed consent was obtained from all participants and/or their legal guardians.

Figures

Fig. 1
Fig. 1
Stratification of cognitive impairment, relationship between body composition and severity of osteoporosis. a The relationship between fat free mass, cognitive function, and severity of osteoporosisb The relationship between height, cognitive function, and severity of osteoporosisc The relationship between weight, cognitive function, and severity of osteoporosisAbbreviations:T1,Severe osteoporosis；T2,osteoporosis;CI, Cognitive impairment
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