Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1985 Sep;20(3):235-7.
doi: 10.1111/j.1365-2125.1985.tb05066.x.

The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow

P A Meredith, F Pasanisi, H L Elliott, J L Reid
Clinical Trial

The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow

P A Meredith et al. Br J Clin Pharmacol. 1985 Sep.

Abstract

The effects of the acute and continued administration of the calcium antagonist nisoldipine on hepatic and renal blood flow and on renal function were studied in nine normotensive volunteers. There were no significant changes in supine blood pressure or heart rate but acute administration significantly increased both apparent liver blood flow and effective renal plasma flow. With continued administration these increases were attenuated and were not significantly different from placebo after 4 days treatment. Acute nisoldipine administration was also associated with significant increases in glomerular filtration rate and urinary sodium excretion.

PubMed Disclaimer

References

    1. Clin Pharmacokinet. 1979 Nov-Dec;4(6):433-48 - PubMed
    1. Nihon Jinzo Gakkai Shi. 1981 Aug;23(8):1143-51 - PubMed
    1. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):67-71 - PubMed
    1. Clin Pharmacol Ther. 1983 Sep;34(3):316-23 - PubMed
    1. Br J Clin Pharmacol. 1984 Jan;17(1):83-5 - PubMed

Publication types

LinkOut - more resources