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Comparative Study
. 2025 Nov;27(11):4177-4184.
doi: 10.1007/s12094-025-03943-9. Epub 2025 May 25.

Heart substructure exposure during left breast cancer radiotherapy: a dosimetric comparison between hybrid VMAT and 3DCRT in free breathing and deep inspiration breath hold (DIBH)

Ingrid Romera-Martínez  1   2 , Irene Oliveras Cancio  3 , Maria Buxó  4 , Joan Martínez  4 , Rafael Fuentes-Raspall  5   3   6 , Arantxa Eraso Urién  5   7 , Joan Carles Vilanova  6   8
Affiliations
Comparative Study

Heart substructure exposure during left breast cancer radiotherapy: a dosimetric comparison between hybrid VMAT and 3DCRT in free breathing and deep inspiration breath hold (DIBH)

Ingrid Romera-Martínez et al. Clin Transl Oncol. 2025 Nov.

Abstract

Background and purpose: Radiotherapy plays a pivotal role in breast cancer treatment. Incidental irradiation of the heart can cause cardiac toxicity. We conducted a dosimetric comparison between Hybrid VMAT (H-VMAT) and 3D Conformal Radiotherapy (3DCRT) in both Free Breathing (FB) and Deep inspiration breath hold (DIBH) techniques for left-sided breast cancer patients.

Materials and methods: Thirty-seven patients underwent CT scans in both FB and DIBH positions. Heart substructures were delineated following established guidelines. Subsequently, 3DCRT and H-VMAT plans were generated for each patient in both breath techniques. The dosimetric parameters of heart and its cavities were analysed: Dmean(Gy) and V5Gy(%) for heart substructures, Dmean(Gy), V25Gy(%) and V30Gy(cm3) for heart and D98%(%), D2%(%), D50%(%) and V95%(%) or V90%(%) for PTVs. Statistical analyses were performed.

Results: The analysis revealed statistically significant differences for the heart, and its cavities. The 3DCRT plans generated in DIBH offered a statistically significant lower dose for the heart and its substructures compared to the other techniques. When comparing PTV dosimetry, the H-VMAT plans showed an increase D98%(%) and a decrease D2%(%) relative to the 3DCRT plans, for both breathing techniques employed.

Conclusion: Our study demonstrates significant differences in the dosimetric outcomes for the heart substructures among the four evaluated techniques, with 3DCRT in DIBH yielding the lowest parameters for most substructures. Although H-VMAT provided superior target coverage, it resulted in greater low doses incidental exposure of the heart substructures. Notably, 3DCRT plans in the DIBH setting exhibited lower doses compared to H-VMAT in FB, supporting its preferential use for minimising cardiac exposure.

Keywords: Breast cancer; Cavities; Dosimetry; Heart; Hybrid VMAT; Radiotherapy.

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Conflict of interest statement

Decalaration. Conflict of interest: The authors declare that there are no financial or non-financial conflicts of interest related to the work presented. Consent to participate: The research involved human participants, and informed consent was obtained from all participants.

References

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