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Review
. 2025 Jul;14(3):395-410.
doi: 10.1016/j.iccl.2024.09.001.

Patent Foramen Ovale and Atrial Septal Defect

Affiliations
Review

Patent Foramen Ovale and Atrial Septal Defect

Joe Aoun et al. Interv Cardiol Clin. 2025 Jul.

Abstract

Patent foramen ovale (PFO) and atrial septal defects (ASDs) are two types of interatrial communications with unique clinical presentations and management strategies. The PFO is a normal part of fetal development that typically closes shortly after birth but may persist in as many as 25% to 30% of adults. The communication between atria may result in paradoxic embolism and embolic stroke. On the other hand, ASDs (anatomically defined as secundum, primum, sinus venosus, and coronary sinus in order of prevalence) typically result in right heart volume overload and are often associated with other congenital defects. The diagnostic methods, treatment options including surgical and percutaneous approaches, and potential complications are described. Both conditions underline the significance of precise diagnosis and appropriate management to mitigate risks and ensure optimal patient outcomes.

Keywords: Atrial septal defect; Echocardiography; Patent foramen ovale; Transcatheter closure.

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Conflict of interest statement

Disclosure C.H. Lin is a proctor for Abbott.

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