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Case Reports
. 2025 Jul 7;87(7):798-803.
doi: 10.1292/jvms.25-0097. Epub 2025 May 26.

Successful treatment of patent ductus arteriosus and severe pulmonary hypertension using sildenafil and beraprost sodium in two dogs

Keisuke Sugimoto  1 , Yohei Mochizuki  1 , Takamasa Itoi  1 , Kanako Tsuji  1 , Asuka Iwano  1 , Yuki Shimizu  1 , Yuko Wada  1 , Teppei Kanda  1
Affiliations
Case Reports

Successful treatment of patent ductus arteriosus and severe pulmonary hypertension using sildenafil and beraprost sodium in two dogs

Keisuke Sugimoto et al. J Vet Med Sci. .

Abstract

Two dogs with patent ductus arteriosus and severe pulmonary hypertension were presented to our veterinary teaching hospital. In both dogs, sildenafil was initiated to treat pulmonary hypertension, and surgery was supposed to be scheduled after dose titration. Although no obvious improvement in pulmonary hypertension was observed, no dog had polycythaemia or an increased haematocrit level. The dogs underwent ductal occlusion, and treatment with beraprost sodium was subsequently initiated. Thereafter, severe pulmonary hypertension dramatically improved. No dog showed any clinical sign of right heart failure or adverse drug reaction postoperatively, thereby demonstrating the successful treatment of two dogs with patent ductus arteriosus and severe pulmonary hypertension, using sildenafil and beraprost sodium.

Keywords: bidirectional shunt; ductus arteriosus; ductus closure; polycythaemia; right heart failure.

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Conflict of interest statement

No conflicts of interest have been declared.

Figures

Fig. 1.
Fig. 1.
Bidirectional shunt (Cases 1 and 2). In case 1, an enlarged ductus arteriosus was observed, and bidirectional blood flow was detected through the ductus arteriosus (A, B, and C). In case 2, an enlarged ductus arteriosus was observed, and trivial blood flow was detected through the ductus arteriosus (D, E, and F).
Fig. 2.
Fig. 2.
Thoracic radiography (Case 1). Pleural effusion was suspected during the first examination (A and B). Three days postoperatively, no obvious changes were observed in the cardiac silhouette (C and D). One month postoperatively, enlargement of the right heart and bulging of the main pulmonary artery had improved (E and F).
Fig. 3.
Fig. 3.
Echocardiography (Case 1). During the first examination, enlargement of the right atrium and ventricle and ventricular septal flattening were observed (A, B, and C). Three days postoperatively, complete occlusion was confirmed, although enlargement of the right atrium and ventricle and ventricular septal flattening persisted (D, E, and F). Both findings had improved 1 month postoperatively (G, H, and I).
Fig. 4.
Fig. 4.
Thoracic radiography (Case 2). During the first examination, enlargement of the right heart and bulging of the main pulmonary artery were observed (A and B). Three days postoperatively, no obvious changes were observed in the cardiac silhouette (C and D). These findings had improved 3 months postoperatively (E and F).
Fig. 5.
Fig. 5.
Echocardiography (Case 2). During the first examination, enlargement of the right atrium and ventricle and severe ventricular septal flattening were observed (A, B, and C). Three days postoperatively, complete occlusion was confirmed, although enlargement of the right atrium and ventricle and ventricular septal flattening persisted (D, E, and F). Both findings had improved 3 months postoperatively (G, H, and I).
See this image and copyright information in PMC

References

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