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. 2025 May 26;10(1):173.
doi: 10.1038/s41392-025-02260-5.

De novo induction of tertiary lymphoid structures: an immunotherapeutic strategy in pancreatic cancer

Azaz Ahmed  1   2 , Christoph Springfeld  2 , Niels Halama  3   4
Affiliations

De novo induction of tertiary lymphoid structures: an immunotherapeutic strategy in pancreatic cancer

Azaz Ahmed et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Overview with central proposed elements of tertiary lymphoid structure (TLS) lymphoneogenesis in mouse models. IL-33 produced in the gut of PDAC-bearing mice leads to migration of KLRG1+ ILC2 cells towards the tumor and interaction with CD11b+ myeloid helper cells. This in turn attracts B cells (and T cells) to form TLSs (as shown in the schematic pixelated TLS representation). The induction of TLSs was recapitulated in mice treated with the human drug candidate H-rIL-33
See this image and copyright information in PMC

References

    1. Amisaki, M. et al. IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer. Nature638, 1076–1084 (2025). - PMC - PubMed
    1. Siegel, R. L., Kratzer, T. B., Giaquinto, A. N., Sung, H. & Jemal, A. Cancer statistics, 2025. CA Cancer J. Clin.75, 10–45 (2025). - PMC - PubMed
    1. Vanhersecke, L. et al. Standardized pathology screening of mature tertiary lymphoid structures in cancers. Lab Investig.103, 100063 (2023). - PubMed
    1. Ahmed, A. et al. Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma. Oncoimmunology11, 2027148 (2022). - PMC - PubMed
    1. Italiano, A. et al. Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort. Nat. Med.28, 1199–1206 (2022). - PubMed

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