The Potential of Near-Infrared Spectroscopy as a Therapeutic Tool Following a Stroke (Review)

Abstract

The advancement of novel technologies for the rehabilitation of post-stroke patients represents a significant challenge for a range of interdisciplinary fields. Near-infrared spectroscopy (NIRS) is an optical neuroimaging technique based on recording local hemodynamic changes at the cerebral cortex level. The technology is typically employed in post-stroke patients for diagnostic purposes, including the assessment of neuroplastic processes accompanying therapy, the study of hemispheric asymmetry, and the examination of functional brain networks. However, functional NIRS can also be used for therapeutic purposes, including the provision of biofeedback during rehabilitation tasks, as well as the navigation method during transcranial stimulation. The effectiveness of therapeutic NIRS application in stroke patients remains insufficiently studied, despite existing scientific evidence confirming its promising potential as a treatment method. The review examines the published literature on the therapeutic applications of NIRS after stroke, evaluating its potential role in the rehabilitation process. The paper describes NIRS features, advantages, and disadvantages, determining its position among other neuroimaging technologies; analyzes the findings of neurophysiological studies, which justified the clinical trials of NIRS technology; and evaluates the results of the studies on the therapeutic use of NIRS in post-stroke patients. Two potential applications of NIRS for therapeutic purposes following a stroke were suggested: the first was to provide real-time feedback during movement training (motor or ideomotor ones, including that in brain-computer interface circuits), and the second was to facilitate navigation during transcranial stimulation. Based on a comprehensive literature review, there were proposed and justified further research lines and development in this field.

Keywords: near-infrared spectroscopy; neurofeedback; neuroimaging; neurological rehabilitation; neuromodulation; stroke.

Signal origin and local cortical activation markers in performing functional nearinfrared spectroscopy (adapted from [8] and [9])

HbO — oxygenated hemoglobin, HbR — reduced hemoglobin, HbT — total hemoglobin, ΔС — concentration change