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. 2025 May 20:18:2619-2628.
doi: 10.2147/IJGM.S516938. eCollection 2025.

Correlation Between Macular Microstructural Changes with Disease Staging and Visual Acuity in Diabetic Retinopathy

Wenhua Zhang  1 , Feng Zhang  1 , Yezhen Yang  1 , Jiamin Cao  1 , Ziyi Zhu  1
Affiliations

Correlation Between Macular Microstructural Changes with Disease Staging and Visual Acuity in Diabetic Retinopathy

Wenhua Zhang et al. Int J Gen Med. .

Abstract

Purpose: To investigate the changes in macular microvascular structure at different stages of diabetic retinopathy (DR) and the correlation between macular ischemia and visual acuity.

Patients and methods: A prospective cross-sectional study was conducted. A total of 173 patients with DR were enrolled and divided into three groups according to DR stage. The control group consisted of 29 gender and age matched healthy individuals. Macular perfusion indexes were measured by optical coherence tomography angiography (OCTA) and compared.

Results: The p-values of central foveal thickness (CFT), focal avascular zone (FAZ) area, and vessel density were less than 0.05 in DR patients and healthy individuals. As the severity of DR increased, there was a corresponding decline in visual acuity, the logMAR best corrected visual acuity (BCVA) was 0.40±0.30 in mild-moderate NPDR, then worsened to 0.48 ± 0.30 (p=0.059) in severe NPDR and further to 0.60 ± 0.34 (p=0.043) in PDR. Superficial capillary plexus (SCP) vessel density correlated negatively with logMAR BCVA (p<0.001, R=-0.267), whereas the severity of DR correlated positively with logMAR BCVA (p<0.001, R=0.199). And increased DR stage was associated with significant reductions in foveal density at 300 μm (FD-300 μm; p=0.004) and deep capillary plexus (DCP) vessel density (p=0.009).

Conclusion: Macular perfusion status decreases as DR progresses. Early changes of macular microvascular structure in different capillary plexus may indicate progression of DR severity and affect visual acuity.

Keywords: OCT angiography; diabetic retinopathy; macular perfusion status; visual acuity.

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Conflict of interest statement

The authors declare that they have no competing interests in this work.

Figures

Figure 1
Figure 1
OCTA images in healthy controls and in patients with mild-moderate NPDR, severe NPDR, and PDR. (6*6mm). The red areas indicate the locations of FAZ area measurements.
Figure 2
Figure 2
BCVA, CFT and macular perfusion indexes in healthy controls and in patients with mild-moderate NPDR, severe NPDR, and PDR. *p < 0.05, **p < 0.001 compared with the control group.
Figure 3
Figure 3
Typical changes of macular perfusion status at different plexus in eyes with mild-moderate NPDR, severe NPDR, and PDR.
Figure 4
Figure 4
Correlation of BCVA and macular perfusion indices.
Figure 5
Figure 5
FA and OCTA determinations of retinal perfusion status and macular ischemia in patients with NPDR and PDR. Red boxes indicate that the FA images was cropped to 6×6 mm, equalling the sizes of the OCTA images.
See this image and copyright information in PMC

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