Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May;41(5):451-459.
doi: 10.1051/medsci/2025071. Epub 2025 May 26.

[Neurodevelopment: a transnosographic dimension]

[Article in French]
Anton Iftimovici  1 , Renaud Jardri  2 , Aline Lefebvre  3 , Jasmina Mallet  4 , Antoine Lefrere  5
Affiliations
Review

[Neurodevelopment: a transnosographic dimension]

[Article in French]
Anton Iftimovici et al. Med Sci (Paris). 2025 May.

Abstract
in English, French

The neurodevelopmental dimension represents a major challenge for the future of precision psychiatry. It provides a transdiagnostic framework, that allows for the redefinition of psychiatric disorders beyond traditional diagnostic categories, such as autism spectrum disorders, attention-deficit/hyperactivity disorder, schizophrenia, and bipolar disorder. This model is based on the identification of deviations in brain developmental trajectories during critical periods of vulnerability. Using multimodal approaches that integrate clinical, biological, neuroimaging, and neurophysiological data, this framework aims to define an individualized neurodevelopmental burden, opening up new prospects for stratification and the development of personalized treatments tailored to each developmental profile.

Title: Le neurodéveloppement - Une dimension transnosographique.

Abstract: La dimension neurodéveloppementale est un enjeu majeur pour l’avenir de la psychiatrie de précision. Elle propose un cadre transnosographique, offrant la possibilité de redéfinir les troubles psychiatriques au-delà des catégories diagnostiques classiques, tels que les troubles du spectre de l’autisme, le trouble du déficit de l’attention avec ou sans hyperactivité, la schizophrénie, et le trouble bipolaire. Ce modèle repose sur l’identification de déviations dans les trajectoires du développement cérébral à des périodes critiques de vulnérabilité. Grâce à des approches multimodales combinant des données cliniques, biologiques, de neuroimagerie et de neurophysiologie, cette approche vise à définir une charge neurodéveloppementale individualisée, ouvrant de nouvelles perspectives de stratification et de traitements personnalisés adaptés à chaque profil développemental.

PubMed Disclaimer

References

    1. Morris-Rosendahl DJ, Crocq MA. Neurodevelopmental disorders: the history and future of a diagnostic concept. Dialogues Clin Neurosci 2020 ; 22 : 65–72.
    1. Stigler SM. Darwin, Galton and the Statistical Enlightenment. Darwin, Galton and statistical enlightenment. JR Stat Soc SerA Stat Soc 2010 ; 173 : 469–82.
    1. Casey BJ, Oliveri ME, Insel T. A neurodevelopmental perspective on the research domain criteria (RDoC) framework. Biol Psychiatry 2014 ; 76 : 350–3.
    1. Eberhard D, Billstedt E, Gillberg C. Neurodevelopmental disorders and comorbidity in young adults attending a psychiatric outpatient clinic. Psychiatry Res 2022 ; 313 : 114638.
    1. Fusar-Poli L, Brondino N, Politi P, et al. Missed diagnoses and misdiagnoses of adults with autism spectrum disorder. Eur Arch Psychiatry Clin Neurosci 2022 ; 272 : 187–98.

LinkOut - more resources