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. 2025 Aug;118(2):301-303.
doi: 10.1002/cpt.3734. Epub 2025 May 26.

Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al

Affiliations

Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al

John O Miners et al. Clin Pharmacol Ther. 2025 Aug.
No abstract available

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Conflict of interest statement

The authors declared no competing interests for this work.

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References

    1. Miners, J.O. , Polasek, T.M. , Hulin, J.‐A. , Rowland, A. & Meech, R. Drug‐drug interactions that alter the exposure of glucuronidated drugs: scope, UDP‐glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance. Pharmacol. Ther. 248, 108459 (2023). - PubMed
    1. Dong, G. et al. Inhibition of OATP1B1/3 rather than UGT1A1 may be the major cause of the bilirubin elevation after atazanavir administration. Clin. Pharmacol. Ther. (2024). 10.1002/cpt.3529. - DOI - PMC - PubMed
    1. Briz, O. , Serrano, M.A. , Macias, R.I.R. , Gonzalez‐Gallego, J. & Marin, J.J.G. Role of organic anion‐transporting polypeptides, OATP‐A. OATP‐C and OATP‐8, in the human placenta‐maternal liver tandem excretory pathway of foetal bilirubin. Biochem. J. 371, 897–905 (2003). - PMC - PubMed
    1. Cui, Y. , Konig, J. , Leier, I. , Buchholz, U. & Keppler, D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 276, 9626–9630 (2001). - PubMed
    1. Zhou, J. , Tracy, T.S. & Remmel, R.P. Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1. Drug Metab. Dispos. 38, 1907–1911 (2010). - PMC - PubMed

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