Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al
- PMID: 40418110
- PMCID: PMC12272321
- DOI: 10.1002/cpt.3734
Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al
Conflict of interest statement
The authors declared no competing interests for this work.
References
-
- Miners, J.O. , Polasek, T.M. , Hulin, J.‐A. , Rowland, A. & Meech, R. Drug‐drug interactions that alter the exposure of glucuronidated drugs: scope, UDP‐glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance. Pharmacol. Ther. 248, 108459 (2023). - PubMed
-
- Cui, Y. , Konig, J. , Leier, I. , Buchholz, U. & Keppler, D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 276, 9626–9630 (2001). - PubMed
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