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Meta-Analysis
. 2025 May 23;104(21):e42447.
doi: 10.1097/MD.0000000000042447.

The association between genetic polymorphisms in GCKR and gout: A systematic review and meta-analysis

Zheng Xi  1 , Ping Dong
Affiliations
Meta-Analysis

The association between genetic polymorphisms in GCKR and gout: A systematic review and meta-analysis

Zheng Xi et al. Medicine (Baltimore). .

Abstract

Background: As far as we know, there are no studies summarizing single nucleotide polymorphism (SNP) in the GCKR gene associated with gout, and the association of SNP in the GCKR gene with gout is controversial.

Methods: Studies were obtained from PubMed, Embase, Web of Science, and Cochrane Library, last searched on February 20, 2024. We reviewed the reported SNP loci of the GCKR gene associated with gout. A meta-analysis was performed to examine the association of SNPs with gout and to investigate whether this association was consistent across populations.

Results: A total of 11 studies were included. 4 GCKR gene SNP loci associated with gout were identified, namely rs780094, rs1260326, rs6547694, rs780093. Meta-analysis showed that SNPs of the GCKR gene were significantly associated with gout (odds ratio [OR]: 1.27; 95% confidence intervals [CI]: 1.21-1.34). Rs780094 (OR: 1.38; 95%CI:1.31-1.44), rs1260326 (OR: 1.26; 95%CI: 1.13-1.39), and rs780093 (OR: 1.17; 95%CI: 1.06-1.27) were all significantly associated with gout. There were no statistically significant differences in effect sizes for rs780094, rs1260326, and rs780093 across populations.

Conclusions: We identified 4 SNPs of the GCKR gene associated with gout and demonstrated that all these SNPs are important genetic factors for gout risk.

Keywords: gout; meta-analysis; single nucleotide polymorphism.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Literature screening process.
Figure 2.
Figure 2.
Effect size estimates and 95% confidence intervals for all SNPs on gout (allelic model). SNP = single nucleotide polymorphism.
Figure 3.
Figure 3.
The effect sizes of each SNP on gout respectively. (A) rs1260326 on gout; (B) rs780094 on gout; (C) rs780093 on gout. SNP = single nucleotide polymorphism.
Figure 4.
Figure 4.
Sensitivity analysis of the effect of GCKR gene on gout.
See this image and copyright information in PMC

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