cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification

Cynthia Hawkins¹, Kenneth Aldape², David Capper^{3

4}, Andreas von Deimling^{5

6}, Caterina Giannini^{7

8}, Mark R Gilbert⁹, Thomas S Jacques¹⁰, David Jones¹¹, Takashi Komori¹², David N Louis¹³, Sabine Mueller^{14

15}, MacLean Nasrallah¹⁶, Brent A Orr¹⁷, Arie Perry¹⁸, Stefan M Pfister^{19

20}, Felix Sahm^{5

6}, Chitra Sarkar²¹, Matija Snuderl²², David Solomon²³, Pascale Varlet²⁴, Pieter Wesseling^{25

26}, Guido Reifenberger²⁷

Affiliations

¹ Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
² Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
³ Department of Neuropathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁴ German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
⁶ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
⁷ Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
⁸ Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, Bologna, Italy.
⁹ Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
¹⁰ UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children, London, UK.
¹¹ Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
¹² Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
¹³ Department of Pathology, Massachusetts General Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
¹⁴ Department of Neurology, Neurosurgery, and Pediatrics, University of California San Francisco, San Francisco, California, USA.
¹⁵ Department of Pediatric, University of Zurich, Zurich, Switzerland.
¹⁶ Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁷ Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
¹⁸ Department of Pathology, University of California San Francisco, San Francisco, California, USA.
¹⁹ Hopp Children's Cancer Center Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
²⁰ Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
²¹ Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
²² Department of Pathology, New York University Langone Health and Grossman School of Medicine, New York, New York, USA.
²³ Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
²⁴ Department of Neuropathology, GHU Paris-Psychiatry and Neuroscience, Sainte-Anne Hospital, Paris, France.
²⁵ Department of Pathology, Amsterdam University Medical Centers/VU University, Amsterdam, The Netherlands.
²⁶ Laboratory for Childhood Cancer Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
²⁷ Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

PMID: 40420507
DOI: 10.1111/bpa.70018

cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification

Cynthia Hawkins et al. Brain Pathol. 2025.

. 2025 May 26:e70018.

doi: 10.1111/bpa.70018. Online ahead of print.

Authors

Affiliations

¹ Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
² Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
³ Department of Neuropathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁴ German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
⁶ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
⁷ Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
⁸ Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, Bologna, Italy.
⁹ Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
¹⁰ UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children, London, UK.
¹¹ Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
¹² Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
¹³ Department of Pathology, Massachusetts General Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
¹⁴ Department of Neurology, Neurosurgery, and Pediatrics, University of California San Francisco, San Francisco, California, USA.
¹⁵ Department of Pediatric, University of Zurich, Zurich, Switzerland.
¹⁶ Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁷ Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
¹⁸ Department of Pathology, University of California San Francisco, San Francisco, California, USA.
¹⁹ Hopp Children's Cancer Center Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
²⁰ Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
²¹ Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
²² Department of Pathology, New York University Langone Health and Grossman School of Medicine, New York, New York, USA.
²³ Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
²⁴ Department of Neuropathology, GHU Paris-Psychiatry and Neuroscience, Sainte-Anne Hospital, Paris, France.
²⁵ Department of Pathology, Amsterdam University Medical Centers/VU University, Amsterdam, The Netherlands.
²⁶ Laboratory for Childhood Cancer Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
²⁷ Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

PMID: 40420507
DOI: 10.1111/bpa.70018

No abstract available

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References

REFERENCES

1. Virchow R. Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre. Zwanzig Vorlesungen, gehalten während der Monate Februar, März und April 1858 im pathologischen institute zu Berlin. Berlin: A. Hirschwald; 1858.
1. Bailey P, Cushing H. A classification of the tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. Philadelphia, PA, London: J.B. Lippincott Company; 1926.
1. Sobin LH. A coded compendium of the international histological classification of tumours. Geneva, Chicago, IL: World Health Organization. Available from: American Society of Clinical Pathologists, continuing education services; 1978. https://iris.who.int/handle/10665/39629
1. Zülch K. Histological typing of tumours of the central nervous system, International Histological Classification of Tumours, No. 21. Geneva: World Health Organization; 1979.
1. EXPERT committee on health statistics. World Health Organ Tech Rep Ser. 1952;53:1–54.

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cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification

Affiliations

cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification

Authors

Affiliations

References

REFERENCES

Publication types

Grants and funding