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. 2025 May;8(3):e70063.
doi: 10.1002/edm2.70063.

Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh

Abu Taher  1 , Aporajita Das Trisha  1 , Shamim Ahmed  1 , Jannat Begum  1 , Falguni Sinha  1 , Nusrat Zaman Sarna  1 , Nurshad Ali  1
Affiliations

Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh

Abu Taher et al. Endocrinol Diabetes Metab. 2025 May.

Abstract

Objectives: While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.

Methods: This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.

Results: The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (p < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (p < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (p < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male-female groups separately (at least p < 0.05). Furthermore, a significant association (p < 0.001) was found between SUA and individual lipid components in the regression models.

Conclusion: Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.

Keywords: Bangladesh; cardiovascular disease; dyslipidemia; serum uric acid; young adults.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flow chart of sampling.
FIGURE 2
FIGURE 2
Prevalence of dyslipidemia and its components in the hyperuricemia and non‐hyperuricemia group. p < 0.001 when the prevalence of dyslipidemia and its individual components is compared between the groups. p‐values are obtained from the Chi‐squared test.
FIGURE 3
FIGURE 3
Correlation of serum uric acid with TG (A), TC (B), HDL (C) and LDL (D). The scale range in the Y‐axis is not the same for all figures.
See this image and copyright information in PMC

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