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. 2025 May 12:17:1523642.
doi: 10.3389/fnagi.2025.1523642. eCollection 2025.

Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study

Jirun Wang #  1 , Shaoqi Tian #  2 , Lei Zhang  1 , Jia Liu  1 , Yuefang Liu  1 , Lei Zhu  1 , Peipei Shan  3 , Ping Zhao  4 , Yang Zhao #  1 , Youzhuang Zhu  1   4
Affiliations

Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study

Jirun Wang et al. Front Aging Neurosci. .

Abstract

Introduction: Frailty is characterized by a decline in multiple physiological systems, increasing vulnerability to stressors such as surgery and anesthesia. A decline in intrinsic capacity is common among elderly populations and has been demonstrated to be a predictor of frailty in community-dwelling seniors. However, the relationship between preoperative intrinsic capacity decline and postoperative frailty in surgical patients remains unclear.

Methods: This study is a single-center, prospective, cohort study. The study will recruit participants aged 60 years and above who are scheduled to undergo elective colorectal surgery. Participants will be classified into an exposed group (intrinsic capacity score ≤ 8) and a non-exposed group (intrinsic capacity score ≥ 9) according to their preoperative intrinsic capacity assessment. The primary outcome is the risk of frailty in elderly patients with impaired intrinsic capacity within one year following colorectal surgery. The secondary outcomes include postoperative pain scores, sleep quality, recovery quality, grip strength, fall risk, activities of daily living, onset time of moderately frailty, incidence of moderately frailty, and adverse events. All assessments will be conducted at predetermined intervals through face-to-face interviews during hospitalization and via telephone follow-up post-discharge.

Discussion: This study aims to clarify the risk of postoperative frailty in older patients with impaired intrinsic capacity. This study seeks to enable the early identification of patients with impaired intrinsic capacity, allowing for the implementation of targeted interventions to reduce the risk of postoperative frailty.

Keywords: cohort study; colorectal surgery; elderly patients; frailty; intrinsic capacity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Participants exposure, outcome measures, and follow-up.
FIGURE 2
FIGURE 2
CFS classification tree.
See this image and copyright information in PMC

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