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. 2025 Jul;56(7):e165-e167.
doi: 10.1161/STROKEAHA.124.050033. Epub 2025 May 27.

Amyloid Presence in Acute Ischemic Stroke Thrombi: Observational Evidence for Fibrinolytic Resistance

Justine M Grixti  1 , Arun Chandran  2 , Jan-Hendrik Pretorius  3 , Melanie Walker  4 , Alakendu Sekhar  2 , Etheresia Pretorius  1   5 , Douglas B Kell  1   5   6
Affiliations

Amyloid Presence in Acute Ischemic Stroke Thrombi: Observational Evidence for Fibrinolytic Resistance

Justine M Grixti et al. Stroke. 2025 Jul.
No abstract available

Keywords: amyloid; fibrin; humans; stroke; thrombectomy.

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Conflict of interest statement

Dr Pretorius is a named inventor on a patent application related to fluorescence methods for microclot detection in long COVID. D.B. Kell is on the Scientific Advisory Board of Daye, is a non-Executive Director of Innotivedx, and holds shares in these companies. The funders had no role in study design, data collection, analysis, interpretation, or publication decisions. The other authors report no conflicts.

Figures

Figure.
Figure.
Fluorescence images of thrombi from 8 patients with acute ischemic stroke (AIS), each stained with thioflavin T to indicate amyloid content. Each part (A–F) represents a sample from a separate patient, with green fluorescence highlighting the presence and distribution of amyloid within the thrombi. The intensity and pattern of amyloid staining vary across the samples, reflecting heterogeneity in amyloid content and distribution. These images visually demonstrate the prevalence of amyloid within AIS thrombi, and its heterogeneity, which may contribute to their resistance to fibrinolysis.
See this image and copyright information in PMC

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