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. 2025 Jul;18(7):e202500130.
doi: 10.1002/jbio.202500130. Epub 2025 May 27.

Design and Analysis of a Novel Nanoscale 2D Photonic Crystal Structure for Enhanced Multi-Disorder Biosensing

K Bhuvaneshwari  1 , B Elizabeth Caroline  2 , J Vidhya  2 , K Sagadevan  2
Affiliations

Design and Analysis of a Novel Nanoscale 2D Photonic Crystal Structure for Enhanced Multi-Disorder Biosensing

K Bhuvaneshwari et al. J Biophotonics. 2025 Jul.

Abstract

A 2D nano-scale multipurpose diamond-shaped ring resonator photonic crystal (PhC) biosensor with 15 × 11 circular silicon (Si) rods in a triangular lattice arrangement is proposed in this article. The distinct feature of the suggested biosensor is the design of a nano-cavity with two different rod radii. The designed biosensor is intended for identifying diabetic blood samples, malaria, and chikungunya virus. The proposed biosensor achieves a high quality factor (QF) of 8080, a high sensitivity (S) of 1108 nm/RIU with a low detection limit (DL) of 9.02 × 10-6 RIU, towards breast cancer analysis. The QF, S, and DL of the biosensor for the diabetic blood sample are 6963, 1087 nm/RIU, and 1.01 × 10-5 RIU respectively. The highest QF and sensitivity of the biosensor are 8561 and 1121.6 nm/RIU respectively, towards malarial detection. A high QF of 9129.4 and a high sensitivity of 1166.9 is achieved for infected plasma towards chikungunya virus detection.

Keywords: 2D photonic crystal biosensor; FDTD; PWE; breast cancer; chikungunya; diabetes; malaria.

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