Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun;22(6):e70691.
doi: 10.1111/iwj.70691.

Assessing Clinician Consistency in Wound Tissue Classification and the Value of AI-Assisted Quantification: A Cross-Sectional Study

Affiliations

Assessing Clinician Consistency in Wound Tissue Classification and the Value of AI-Assisted Quantification: A Cross-Sectional Study

Heba Talla Mohammed et al. Int Wound J. 2025 Jun.

Abstract

This study investigated the relationship between clinician assessments and the AI-generated scores, highlighting how correlations vary based on clinician expertise. It also explored the proportion of tissue types identified by clinicians relative to AI assessments and assess the inter-clinician agreement in quantifying tissue types, identifying variations based on clinician experience. A cross-sectional survey used purposive, non-random sampling to recruit 50 wound care clinicians. Participants reported their specialisation and experience level before identifying and quantifying granulation, slough, eschar, and epithelialisation in nine wound images. An AI model analysed the same images for comparison. Experienced clinicians and wound care specialists reported higher confidence in assessments. Inter-clinician agreement was moderate-good for granulation and slough (ICC: 0.763-0.762) and moderate-excellent for eschar (ICC: 0.910), but moderate-poor for epithelialisation (ICC: 0.435). Clinicians strongly correlated with AI for granulation, slough, and eschar (r = 0.879, 0.955 and 0.984, respectively). Epithelialisation was more challenging, with a 60% identification rate and moderate correlation with AI (r = 0.579). AI-generated scores aligned with clinician assessments for granulation, slough, and eschar. However, epithelialisation, which is crucial for objectively measuring healing progress, showed greater variability, suggesting that AI could improve the reliability of its assessment, potentially leading to more consistent wound evaluation to guide treatment decisions.

Keywords: AI‐driven wound care; epithelialisation assessment; granulation tissue quantification; inter‐clinician agreement; slough and eschar identification.

PubMed Disclaimer

Conflict of interest statement

H.T.M., R.D.J.F., S.W., Z.L., J.A. and A.C. are all current employees of Swift Medical Inc. The other authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
AI‐wound captured images included in the survey.
FIGURE 2
FIGURE 2
Percentage of clinicians matching AI‐identified presence or absence of tissue types across nine wound images.
FIGURE 3
FIGURE 3
(a) Inter‐clinicians' agreement in quantifying tissue types by experience and practice pattern. (b) Mean tissue percentages identified by clinicians, stratified by experience and practice pattern.
FIGURE 4
FIGURE 4
(a) AI vs. clinicians' scores and correlation between clinician and AI measurements for all participants for each tissue type across wounds. (b) AI vs. specialists' scores and correlation between specialists and AI measurements for each tissue type across wounds. (c) AI vs. experienced clinicians' scores and correlation between scores of clinicians with > 10 years' experience and AI measurements for each tissue type across wounds.

Similar articles

Cited by

References

    1. Swann G., “The Skin Is the Body's Largest Organ,” Journal of Visual Communication in Medicine 33, no. 4 (2010): 148–149, 10.3109/17453054.2010.525439. - DOI - PubMed
    1. Baranoski S. and Ayello E. A., Wound Care Essentials, 3rd ed. (Wolters Kluwer, 2015).
    1. Alhajj M. and Goyal A., “Physiology, Granulation Tissue,” in StatPearls [Internet] (StatPearls Publishing, 2025). - PubMed
    1. Pastar I., Stojadinovic O., Yin N. C., et al., “Epithelialization in Wound Healing: A Comprehensive Review,” Advances in Wound Care (New Rochelle) 3, no. 7 (2014): 445–464. - PMC - PubMed
    1. Flanagan M., “The Characteristics and Formation of Granulation Tissue,” Journal of Wound Care 7, no. 10 (1998): 508–510, 10.12968/jowc.1998.7.10.508. - DOI - PubMed