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. 2025 May 27;151(21):1544-1546.
doi: 10.1161/CIRCULATIONAHA.124.072636. Epub 2025 May 27.

Blood Pressure Lowering Effects of a Novel Long-Acting NPR1 Agonist, XXB750, in Healthy Participants: A Randomized, First-in-Human Clinical Study

YanLing He  1 , Xueping Wu  2 , Andre Serra-Roma  3 , Maggie Markiewicz  4 , Emma Healy  1 , Jing-He Yan  4 , Kenneth Kulmatycki  1 , Tong Zhang  5 , John L Diener  6 , Arvind G Kinhikar  1 , Denise P Yates  1 , David Nguyen  7 , Markus Hinder  3 , Cesare Russo  3 , Christopher J O'Donnell  1
Affiliations

Blood Pressure Lowering Effects of a Novel Long-Acting NPR1 Agonist, XXB750, in Healthy Participants: A Randomized, First-in-Human Clinical Study

YanLing He et al. Circulation. .
No abstract available

Keywords: NPR1 agonist; XXB750; blood pressure; cGMP; natriuretic peptide system.

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Conflict of interest statement

Drs He, Wu, Markiewicz, Healy, Yan, Kulmatycki, Kinhikar, Yates, Hinder, Russo, and O’Donnell are employees of Novartis. Dr Diener was an employee of Novartis until January 2020. Dr Zhang was an employee of Novartis until April 2024. A. Dr Serra-Roma was an employee of Novartis until October 2024. Dr Nguyen is an employee of Altasciences Clinical, which received research support from Novartis for the conduct of this study.

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