Guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection [Internet]
- PMID: 40424433
- Bookshelf ID: NBK614989
Guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection [Internet]
Excerpt
Hepatitis B (HBV) infection is a major public health problem and cause of chronic liver disease.
The 2024 HBV guidelines provide updated evidence-informed recommendations on key priority topics. These include expanded and simplified treatment criteria for adults but now also for adolescents; expanded eligibility for antiviral prophylaxis for pregnant women to prevent mother-to-child transmission of HBV; improving HBV diagnostics through use of point-of-care HBV DNA viral load and reflex approaches to HBV DNA testing; who to test and how to test for HDV infection; and approaches to promote delivery of high-quality HBV services, including strategies to promote adherence to long-term antiviral therapy and retention in care.
The 2024 guidelines include 11 updated chapters with new recommendations and also update existing chapters without new recommendations, such as those on treatment monitoring and surveillance for liver cancer.
© World Health Organization 2024.
Sections
- Acknowledgements
- Abbreviations and acronyms
- Glossary of terms
- Executive Summary
- Summary of recommendations
- 1. Introduction
- 2. Background
- 3. Methods and process of developing the guidelines
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Expanded treatment eligibility
- 4. Non-invasive assessment of liver disease stage
- 5. Who to treat among people with CHB
- 6. First-line antiviral therapies for CHB (adults, adolescents and children)
- 7. Preventing mother-to-child transmission of hepatitis B using antiviral prophylaxis
- 8. Who to treat and what antiviral drugs to use for adolescents and children with CHB
- 9. Second-line antiviral therapies for managing treatment failure
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HBV and HDV diagnostics
- 10. Measuring HBV DNA to guide treatment eligibility and monitor the response
- 11. HBV DNA reflex testing
- 12. Hepatitis D virus (HDV) testing: who to test for HDV infection
- 13. How to test for HDV infection: testing strategy and choice of serological and NAT assays
- 14. How to test for HDV: laboratory-based reflex testing
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HBV service delivery and monitoring
- 15. Approaches to promote delivery of high-quality health services for CHB
- 16. Monitoring for treatment response among people with CHB receiving treatment or not yet receiving treatment
- 17. Monitoring the safety of nucleoside analogues
- 18. Surveillance for hepatocellular carcinoma (HCC) among people with CHB
- 19. When to stop and restart antiviral therapy
- 20. Management considerations for specific populations
- References
- Web annexes
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