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. 1977 Mar;15(3):842-5.
doi: 10.1128/iai.15.3.842-845.1977.

Mitogenic activity of cell wall components from smooth and rough strains of Brucella abortus

D L Kreutzer, J W Scheffel, L R Draper, D C Robertson

Mitogenic activity of cell wall components from smooth and rough strains of Brucella abortus

D L Kreutzer et al. Infect Immun. 1977 Mar.

Abstract

On the basis of [3H]thymidine incorporation by normal mouse spleen cell cultures, cell wall preparations from a smooth (45/0) strain and a rough (45/20) strain of Brucella abortus were strongly mitogenic. On the other hand, none of several subcomponents extracted from the cell wall preparations, including aqueous and phenolic lipopolysaccharides, was active. These results contrast with the marked mitogenic activity of lipopolysaccharides isolated from other gram-negative bacteria such as Salmonella typhimurium.

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