Patient-centered integration of tumor and germline genetic results can improve cancer care

Affiliations

¹ Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. alanna.church@childrens.harvard.edu.
² Department of Biomedical Informatics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
³ USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁴ Department of Integrative Translational Science, Beckman Research Institute, City of Hope, Duarte, CA, USA.
⁵ Department of Surgery, School of Medicine, Washington University, St. Louis, MO, USA.
⁶ Dana-Farber Cancer Institute, Boston, MA, USA.
⁷ MIB Agents Osteosarcoma Alliance, Barnard, VT, USA.
⁸ Clinical Genomics and Therapeutic Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
⁹ Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
¹⁰ Division of Clinical Cancer Genomics, Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA, USA.

^# Contributed equally.

PMID: 40425841
DOI: 10.1038/s41591-025-03686-8

Patient-centered integration of tumor and germline genetic results can improve cancer care

Alanna J Church et al. Nat Med. 2025 Oct.

. 2025 Oct;31(10):3248-3251.

doi: 10.1038/s41591-025-03686-8.

Authors

Affiliations

¹ Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. alanna.church@childrens.harvard.edu.
² Department of Biomedical Informatics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
³ USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁴ Department of Integrative Translational Science, Beckman Research Institute, City of Hope, Duarte, CA, USA.
⁵ Department of Surgery, School of Medicine, Washington University, St. Louis, MO, USA.
⁶ Dana-Farber Cancer Institute, Boston, MA, USA.
⁷ MIB Agents Osteosarcoma Alliance, Barnard, VT, USA.
⁸ Clinical Genomics and Therapeutic Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
⁹ Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
¹⁰ Division of Clinical Cancer Genomics, Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA, USA.

^# Contributed equally.

PMID: 40425841
DOI: 10.1038/s41591-025-03686-8

No abstract available

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Conflict of interest statement

Competing interests: A.J.C. serves as a consultant for Bayer. H.J.L. serves on the advisory board for Fulgent. H.H. serves on the scientific advisory board for Exact Sciences (PreventionGenetics) and Lynsight, serves as a consultant for GI OnDemand, and holds stock in Genome Medical and GI OnDemand.

References

1. Dusic, E. J. et al. Front. Digit. Health 4, 961128 (2022). - DOI - PubMed - PMC
1. Hamze, M. K. et al. Cureus 15, e40184 (2023). - PubMed - PMC
1. Schienda, J. et al. JCO Precision Oncol. 5, 1840–1852 (2021). - DOI
1. Niehaus, A. et al. Genet. Med. 21, 1699–1701 (2019). - DOI - PubMed - PMC
1. Li, M. M. et al. J. Mol. Diagn. 25, 69–86 (2023).

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Patient-centered integration of tumor and germline genetic results can improve cancer care

Affiliations

Patient-centered integration of tumor and germline genetic results can improve cancer care

Authors

Affiliations

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources