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. 2025 Jul;39(7):4329-4334.
doi: 10.1007/s00464-025-11781-7. Epub 2025 May 27.

Role of radiofrequency STRETTA for recurrent GERD following primary anti-reflux surgery and primary STRETTA therapy

Yirupaiahgari Krishnaiah Setty Viswanath  1 , Simon Mbarushimana  1 , Ahmed Ammar  1 , Gowri Pillai Madhusudanan  1 , George Kourounis  1 , Anil Reddy  2
Affiliations

Role of radiofrequency STRETTA for recurrent GERD following primary anti-reflux surgery and primary STRETTA therapy

Yirupaiahgari Krishnaiah Setty Viswanath et al. Surg Endosc. 2025 Jul.

Abstract

Background: Gastroesophageal reflux disease (GERD) is a common chronic condition affecting millions all over the world. It occurs due to the reflux of gastric acid into the oesophagus. Endoscopic therapies like STRETTA offer minimally invasive options to manage GERD. This study aims to evaluate the role of STRETTA in patients with recurrent symptoms after structurally intact hiatus hernia repair with anti-reflux surgery (ARS) and in patients who had an initially successful STRETTA.

Methods: A retrospective review was conducted on patients who underwent STRETTA from 2014 to 2024 at a tertiary centre to identify patients whose STRETTA therapy followed either a primary ARS (OP to STR) or primary STRETTA (STR to STR). Patients' outcomes were assessed before and after the STRETTA procedure using validated RSI (Reflux symptom index), and GERD HRQL (Gastro Esophageal Reflux Disease Health-Related Quality of Life) quality of life (QoL) questionnaires. The use of anti-secretory medications was analysed using Chi-Square (X2) test.

Results: 19 eligible patients were studied under 2 cohorts: 13 underwent STRETTA following a primary ARS (OP to STR) and 6 had a repeat STRETTA following a primary successful STRETTA (STR to STR). The median time from ARS to STRETTA was 8.7 years compared with 5.5 years in the STR to STR group, p = 0.180. The median follow-up in the ARS to STR group was significantly longer at 5.7 years compared to 0.8 years in the STR to STR, p = 0.008. The median age was 66.0 years in ARS to STRETTA group and 54.5 years in the STR to STR cohort. The OP to STR cohort saw a significant reduction in the RSI (Wilcoxon V = 84.5, p = 0.007) and improvement in QoL (Wilcoxon V = 66, p = 0.004). The STR to STR cohort did not show a statistically significant improvement in either RSI (Wilcoxon V = 15, p = 0.058) or QoL scores (Wilcoxon V = 19, p = 0.093). No statistically significant difference was noted in the usage of PPIs in either cohort.

Conclusion: This retrospective, small sample and single-centre study opens the debate about the role of endoscopic radiofrequency STRETTA therapy in selected recurrent GERD patients following successful primary ARS. Furthermore, though our limited data showed no statistically significant benefit in RSI and GERD HRQL for the STR to STR cohort, this is a compelling topic which begs for larger robust studies.

Keywords: Anti-reflux surgery; GERD; QoL; RSI; STRETTA.

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Conflict of interest statement

Declarations. Disclosures: Yirupaiahgari Krishnaiah Setty Viswanath, Simon Mbarushimana, Ahmed Ammar, Gowri Pillai Madhusudanan, George Kourounis and Anil Reddy have no conflict of interest or financial ties to disclose.

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