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. 2025 May 27;25(1):950.
doi: 10.1186/s12885-025-14371-x.

Short-term impact of delayed surgical treatment on the prognosis of patients with T1bN1-stage PTC: a retrospective cohort study

Hao Gong #  1 , Tianyuchen Jiang #  1 , Yi Yang  1 , Yuhan Jiang  1 , Zhujuan Wu  1 , Anping Su  2
Affiliations

Short-term impact of delayed surgical treatment on the prognosis of patients with T1bN1-stage PTC: a retrospective cohort study

Hao Gong et al. BMC Cancer. .

Abstract

Background: As the incidence of papillary thyroid carcinoma (PTC) increases, optimal timing for surgical interventions remains undefined. While surgical delays are known to affect prognosis adversely in various cancers, their impact on PTC is controversial.

Methods: A retrospective study was conducted on 478 T1bN1-stage PTC patients treated at West China Hospital from January 2020 to May 2022. Patients underwent thyroidectomy with lymph node dissection and were categorized into three groups based on surgical delay: ≤90 days (group A, n = 264), > 90-180 days (group B, n = 92), and > 180 days (group C, n = 122). Additionally, patients were reclassified into two groups based on a one-year threshold: ≤365 days (group D, n = 420) and > 365 days (group E, n = 58). Tumor metastasis rates and postoperative complications were analyzed across these groups.

Results: The median surgical delay was 79 days, and the median follow-up was 1362 days. Tumor metastasis occurred in 1.67% (8 patients), while postoperative complications occurred in 5.65% (27 patients). Metastasis rates were 1.89%, 1.09%, and 1.64%, and complication rates were 5.68%, 4.35%, and 6.56% for groups A, B, and C, respectively. No statistically significant differences were observed in metastasis or complication rates among the three groups. Similarly, no significant differences were found between groups D and E in tumor metastasis (p = 1.000) or complication rates (p = 0.555).

Conclusion: Delayed surgery was not associated with significantly increased short-term tumor metastasis or postoperative complication rates in patients with T1bN1-stage PTC.

Keywords: Delayed surgery; Papillary thyroid carcinoma; Postoperative complications.; T1bN1-stage; Tumor metastasis.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This retrospective cohort study was conducted in accordance with the Declaration of Helsinki and received approval from the the Biomedical Ethics Review Committee of West China Hospital, Sichuan University (2024 [2051]), and registration was completed with the Chinese Clinical Trial Registry (ChiCTR2500095113). Given the retrospective nature of the study and the use of anonymized data, the ethics committee waived the requirement for informed consent. Patient data were de-identified prior to analysis to ensure confidentiality and protect privacy. The study was conducted in compliance with local legislation and relevant guidelines. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of surgical delay intervals among patients with T1bN1-stage PTC
Fig. 2
Fig. 2
Kaplan-Meier estimates of tumor metastasis -free survival by surgical waiting times for T1bN1-stage PTC patients
See this image and copyright information in PMC

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