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Review
. 2025 Apr 23;15(5):430.
doi: 10.3390/brainsci15050430.

Perspectives on Precision Psychiatry Using Antipsychotics in the Management of Bipolar Disorder

Michele Fornaro  1 , Alessandro Miola  2   3 , Domenico De Berardis  4 , Alessio Squassina  5   6   7 , Mirko Manchia  5   6   7 , Marco Solmi  8   9   10   11
Affiliations
Review

Perspectives on Precision Psychiatry Using Antipsychotics in the Management of Bipolar Disorder

Michele Fornaro et al. Brain Sci. .

Abstract

Background/objectives: Precision medicine is not just hype. Instead, it represents a high bar for developing more effective, safer, and better-tolerated therapies in medicine, without exception in psychiatry, including bipolar disorder (BD). A burgeoning body of narrative reviews and perspective papers has already appraised the boundaries of precision medicine in BD.

Methods: This brief perspective follows a narrative, critical approach focusing explicitly on the antipsychotic management of BD using precision approaches.

Results: While most controversies align with those previously appraised in BD's overall precision medicine approach, specific insights are provided herein.

Conclusions: Beyond other implications and the strengthened call for valid diagnostic coding systems, the implementation of shared decision-making tools and pharmacogenomics studies focusing on persons with BD are particularly warranted.

Keywords: antipsychotic; bipolar disorder; precision medicine; psychopharmacology; shared decision-making.

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Conflict of interest statement

The authors declare no conflict of interest.

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