Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 May 13;15(5):498.
doi: 10.3390/brainsci15050498.

Amyotrophic Lateral Sclerosis: Recent Considerations for Diagnosis, Pathogenesis and Therapy

Affiliations
Editorial

Amyotrophic Lateral Sclerosis: Recent Considerations for Diagnosis, Pathogenesis and Therapy

Andrew Eisen. Brain Sci. .

Abstract

Amyotrophic lateral sclerosis (ALS/MND) is considered a uniquely human complex neurodegenerative disorder, presenting with a variety of clinical phenotypes, which include frontotemporal dementia [...].

PubMed Disclaimer

Conflict of interest statement

There is no conflict of interest.

Similar articles

References

    1. Talbot K. Familial versus sporadic amyotrophic lateral sclerosis—A false dichotomy? Brain. 2011;134:3429–3434. doi: 10.1093/brain/awr296. - DOI - PubMed
    1. Bigio E.H., Weintraub S., Rademakers R., Baker M., Ahmadian S.S., Rademaker A., Weitner B.B., Mao Q., Lee K.H., Mishra M., et al. Frontotemporal lobar degeneration with TDP-43 proteinopathy and chromosome 9p repeat expansion in C9ORF72: Clinicopathologic correlation. Neuropathology. 2013;33:122–133. doi: 10.1111/j.1440-1789.2012.01332.x. - DOI - PMC - PubMed
    1. Chong Z.Z., Souayah N. Pathogenic TDP-43 in amyotrophic lateral sclerosis. Drug Discov. Today. 2025;30:104351. doi: 10.1016/j.drudis.2025.104351. - DOI - PubMed
    1. Strong M.J. The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. 2008;9:323–338. doi: 10.1080/17482960802372371. - DOI - PubMed
    1. Chio A., Mazzini L., D’Alfonso S., Corrado L., Canosa A., Moglia C., Manera U., Bersano E., Brunetti M., Barberis M., et al. The multistep hypothesis of ALS revisited: The role of genetic mutations. Neurology. 2018;91:e635–e642. doi: 10.1212/WNL.0000000000005996. - DOI - PMC - PubMed

Publication types

LinkOut - more resources