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. 2025 May 12;30(10):2132.
doi: 10.3390/molecules30102132.

Antimicrobial, Antioxidant, and α-Glucosidase-Inhibitory Activities of Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia ensiformis

Lu-Lu Wang  1 , Wei Tang  1 , Zhuo Wang  1 , Yi-Xiang Wang  1 , Ning Li  1 , Fu-Cai Ren  1
Affiliations

Antimicrobial, Antioxidant, and α-Glucosidase-Inhibitory Activities of Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia ensiformis

Lu-Lu Wang et al. Molecules. .

Abstract

Seven previously undescribed prenylated p-hydroxybenzoic acid derivatives, oberoniaensiformisins A-G, were isolated from an EtOH extract of the whole plant Oberonia ensiformis. Their structures were determined through spectroscopic analyses (IR, NMR) and HRESIMS analysis. The isolated compounds were tested for their antimicrobial, antioxidant, and α-glucosidase-inhibitory activity. Among them, compounds 6 and 12 exhibited potential antioxidant activity, while compounds 5, 6, 12, 13, and 15 showed varying degrees of α-glucosidase-inhibitory activity, with IC50 values ranging from 34.03 to 106.10 μg/mL.

Keywords: Oberonia ensiformis; antioxidant activity; prenylated aromatic compounds; α-glucosidase-inhibitory activity.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–18.
Figure 2
Figure 2
HMBC correlations of compounds 1–7.
Figure 3
Figure 3
Experimental and calculated ECD spectra of compound 3.
Figure 4
Figure 4
(a,b) Clearance rate of DPPH by compounds in vitro. Values are expressed as means ± SD. The asterisk (*) denotes a novel compound.
Figure 5
Figure 5
(a–e) Inhibition of α-glucosidase by compounds in vitro. Values are expressed as means ± SD. The asterisk (*) denotes a novel compound.
Figure 6
Figure 6
Isolation procedure of chemical constituents of O. ensiformis.
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