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Review
. 2025 May 21;17(10):1415.
doi: 10.3390/polym17101415.

A Scoping Review of Vitamins Detection Using Electrochemically Polymerised, Molecularly Imprinted Polymers

Mohd Azerulazree Jamilan  1   2 , Balqis Kamarudin  1 , Zainiharyati Mohd Zain  2 , Kavirajaa Pandian Sambasevam  2   3 , Faizatul Shimal Mehamod  4 , Mohd Fairulnizal Md Noh  1
Affiliations
Review

A Scoping Review of Vitamins Detection Using Electrochemically Polymerised, Molecularly Imprinted Polymers

Mohd Azerulazree Jamilan et al. Polymers (Basel). .

Abstract

Vitamins are crucial micro-nutrients for overall well-being, making continuous monitoring essential. There are demands to provide an alternative detection, especially using a portable detection or a point-of-care-testing (POCT) device. One promising approach is employing an in situ electro-polymerised MIP (eMIP), which offers a straightforward polymerisation technique on screen-printed electrodes (SPEs). Here, we report a review based on three databases (PubMed, Scopus, and Web of Science) from 2014 to 2024 using medical subject heading (MeSH) terms "electrochemical polymerisation" OR "electropolymerisation" crossed with the terms "molecularly imprinted polymer" AND "vitamin A" OR "vitamin D" OR "vitamin E" OR "vitamin K" OR "fat soluble vitamin" OR "vitamin B" OR "vitamin C" OR "water soluble vitamin". The resulting 12 articles covered the detection of vitamins in ascorbic acid, riboflavin, cholecalciferol, calcifediol, and menadione using monomers of catechol (CAT), 3,4-ethylenedioxythiophene (EDOT), o-aminophenol (oAP), o-phenylenediamine (oPD), pyrrole, p-aminophenol (pAP), p-phenylenediamine (pPD), or resorcinol (RES), using common bare electrodes including graphite rod electrode (GRE), glassy carbon electrode (GCE), gold electrode (GE), and screen-printed carbon electrode (SPCE). The most common electrochemical detections were differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV). The imprinting factor (IF) of the eMIP-modified electrodes were from 1.6 to 21.0, whereas the cross-reactivity was from 0.0% to 29.9%. Several types of food and biological samples were tested, such as supplement tablets, poultry and pharmaceutical drugs, soft drinks, beverages, milk, infant formula, human and calf serum, and human plasma. However, more discoveries and development of detection methods needs to be performed, especially for the vitamins that have not been studied yet. This will allow the improvement in the application of eMIPs on portable-based detection and POCT devices.

Keywords: eMIP; electrochemical detection; fat-soluble vitamin; in situ electro-polymerisation; water-soluble vitamin.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The general overview for the synthesis of MIP.
Figure 2
Figure 2
The summarised search strategy of the study.
Figure 3
Figure 3
The six steps of procedure for the development of eMIP.
See this image and copyright information in PMC

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