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Review
. 2025 May 4;13(5):1073.
doi: 10.3390/microorganisms13051073.

The Relationship Between Gut Microbiota and Recurrent Spontaneous Abortion

Yiyao Huang  1 , Ruijie Fang  1 , Ting Xiong  2 , Wei Li  2 , Nan Yu  2
Affiliations
Review

The Relationship Between Gut Microbiota and Recurrent Spontaneous Abortion

Yiyao Huang et al. Microorganisms. .

Abstract

Recently, the gut microbiota has been found to be associated with multiple organs and systems in the human body, playing a key role in the occurrence and development of various diseases, such as the gut-brain axis and the gut-liver axis. However, its interaction with miscarriages remains poorly understood. This article reviews the characteristics of gut microbiota and its metabolites in patients with recurrent spontaneous abortion (RSA), the mechanism of gut microbiota inducing RSA, and potential therapeutic strategies. Therefore, it provides a new perspective on the gut microbiota in the pathogenesis and treatment of recurrent abortion, and the prospect of the future research direction of gut microbiota and recurrent abortion is proposed based on existing studies.

Keywords: gut microbiota; immunology; recurrent miscarriages; recurrent spontaneous abortion (RSA).

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Gut microbiota and metabolite trigging inflammatory response (Created in BioRender. Yiyao Huang (2024) https://BioRender.com).
Figure 2
Figure 2
Several gut microbiota influencing T cell differentiation (Created in BioRender. Yiyao Huang. (2024)).
Figure 3
Figure 3
Gut microbiota metabolites affecting T cell differentiation (Created in BioRender. Yiyao Huang. (2024)).
See this image and copyright information in PMC

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References

    1. Wang S., Chen L., Feng X. Research progress on the correlation between gut microbiota and recurrent spontaneous abortion of kidney deficiency and blood stasis type. Shaanxi J. Tradit. Chin. Med. 2022;43:261–264+268.
    1. Yang X., Zhang Y., Liu Y., Zhao R. Exploring the treatment of female reproductive disorders from the perspective of spleen and stomach theory based on gut microbiota. Chin. J. Integr. Tradit. West. Med. 2023;43:345–350.
    1. Li Z., Zheng Y., Zhang M., Wu K., Zhang L., Yao Y., Zheng C. Gut microbiota-derived metabolites associate with circulating immune cell subsets in unexplained recurrent spontaneous abortion. Heliyon. 2024;10:e24571. doi: 10.1016/j.heliyon.2024.e24571. - DOI - PMC - PubMed
    1. Weersma R.K., Zhernakova A., Fu J. Interaction between drugs and the gut microbiome. Gut. 2020;69:1510–1519. doi: 10.1136/gutjnl-2019-320204. - DOI - PMC - PubMed
    1. Song Q., Qian X., Chen Q. Research progress on the correlation between gut microbiota and pregnancy complications. Int. J. Reprod. Health/Fam. Plan. 2023;42:409–413.

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