Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2025 May 8;17(10):1604.
doi: 10.3390/nu17101604.

Influence of Structured Medium- and Long-Chain Triglycerides on Muscular Recovery Following Damaging Resistance Exercise

Carina M Velasquez  1 , Christian Rodriguez  1 , Kealey J Wohlgemuth  1 , Grant M Tinsley  1 , Jacob A Mota  1
Affiliations
Randomized Controlled Trial

Influence of Structured Medium- and Long-Chain Triglycerides on Muscular Recovery Following Damaging Resistance Exercise

Carina M Velasquez et al. Nutrients. .

Abstract

Background/Objectives: Structured medium- and long-chain triglycerides (sMLCT) may be a superior vehicle for medium-chain fatty acid delivery to peripheral tissues, such as skeletal muscle. Limited information is available concerning the effect of sMLCT on muscular performance or recovery after a muscle-damaging exercise protocol. The purpose of this study was to establish the effect of a novel formulation of sMLCT on muscular performance and recovery. Methods: Forty female adults (mean ± SD age = 22 ± 3 years; body mass index = 23.5 ± 3.4 kg/m2) were randomized into one of two study groups, placebo control [CON; n = 20] or sMLCT [n = 20], and completed five total visits to the laboratory. The baseline (i.e., pre-exercise) assessments of muscle performance, size, and soreness were compared to assessments immediately following exercise and 24, 48, and 72 h post-exercise. Results: No statistically significant condition × time interactions were noted for strength outcomes, although trends for condition × time interactions were present for torque over 25 ms (p = 0.06) and peak torque (p = 0.05). Similarly, no condition x time interactions were present for ultrasound echo intensity, the subjective ratings of soreness and pain, thigh circumference, leg volume, and vertical jump performance. Conclusions: Within the context of the current study, the ingestion of sMLCT did not significantly influence the rate of muscle strength recovery following muscle damaging resistance exercise.

Keywords: delayed onset muscle soreness; medium-chain triglycerides; muscle damage; recovery; supplements; triglycerides.

PubMed Disclaimer

Conflict of interest statement

G.M.T. has received support for his research laboratory through funding or in-kind gifts from nutrition and sports nutrition companies. G.M.T. is the owner of Tinsley Consulting LLC, which provides paid consulting services to dietary supplement manufacturers. Bunge Loders Croklaan, the sponsor of the present study, is not a past or current client of Tinsley Consulting LLC. J.A.M. has received support for his research laboratory through funding or in-kind gifts from neuromuscular and/or occupational health entities. All the other authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Muscular strength changes. Data displayed as mean ± SE.
Figure 2
Figure 2
Mixed model coefficients for strength models. * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001.
Figure 3
Figure 3
Changes in muscle characteristics. Data displayed as mean ± SE.
Figure 4
Figure 4
Mixed model coefficients for muscle characteristic models. * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001.
Figure 5
Figure 5
Changes in Subjective Variables. Data displayed as mean ± SE.
Figure 6
Figure 6
Mixed model coefficients for subjective variables. * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001.
Figure 7
Figure 7
Changes in thigh anthropometry.
Figure 8
Figure 8
Mixed model coefficients for thigh anthropometry. * indicates p < 0.05; *** indicates p < 0.001.
Figure 9
Figure 9
Changes in vertical jump performance.
Figure 10
Figure 10
Mixed model coefficients for vertical jump performance. * indicates p < 0.05; *** indicates p < 0.001.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Cheung K., Hume P.A., Maxwell L. Delayed onset muscle soreness: Treatment strategies and performance factors. Sports Med. 2003;33:145–164. doi: 10.2165/00007256-200333020-00005. - DOI - PubMed
    1. MacIntyre D.L., Reid W.D., McKenzie D.C. Delayed muscle soreness: The inflammatory response to muscle injury and its clinical implications. Sports Med. 1995;20:24–40. doi: 10.2165/00007256-199520010-00003. - DOI - PubMed
    1. Caballero-García A., Córdova-Martínez A. Muscle recovery and nutrition. Nutrients. 2022;14:2416. doi: 10.3390/nu14122416. - DOI - PMC - PubMed
    1. Romain C., Freitas T.T., Martínez-Noguera F.J., Laurent C., Gaillet S., Chung L.H., Alcaraz P.E., Cases J. Supplementation with a Polyphenol-Rich Extract, TensLess®, Attenuates Delayed Onset Muscle Soreness and Improves Muscle Recovery from Damages After Eccentric Exercise. Phytother. Res. 2017;31:1739–1746. doi: 10.1002/ptr.5902. - DOI - PubMed
    1. Pumpa K.L., Fallon K.E., Bensoussan A., Papalia S. The effects of Lyprinol® on delayed onset muscle soreness and muscle damage in well trained athletes: A double-blind randomised controlled trial. Complement. Ther. Med. 2011;19:311–318. doi: 10.1016/j.ctim.2011.08.004. - DOI - PubMed

Publication types

LinkOut - more resources