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. 2025 Feb 17;2025(1):22.
doi: 10.5339/qmj.2025.22. eCollection 2025.

Clinical outcome of OviTex reinforced tissue matrix in hernia repair: A systematic review and meta-analysis

Ahmad R Al-Qudimat  1   2 , Seif B Altahtamouni  1 , Kalpana Singh  3 , Omar M Aboumarzouk, Mohamed Elakkad  4
Affiliations

Clinical outcome of OviTex reinforced tissue matrix in hernia repair: A systematic review and meta-analysis

Ahmad R Al-Qudimat et al. Qatar Med J. .

Abstract

Background: This review provides a comprehensive and current overview of the clinical outcomes associated with the use of OviTex reinforced tissue matrix (RTM) in hernia repair. Methods: We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our search included research publications related to clinical outcomes involving the use of OviTex RTM in hernia repair up to August 2023. We extensively examined and extracted relevant data from databases such as Embase, PubMed, and Scopus. The meta-analysis included comparisons related to body mass index (BMI) in hernia treatment, primary abdominal wall hernias treated with OviTex, and other relevant factors. The quality of the included studies was assessed using the MINORS (Methodological Index for Non-Randomized Studies) scale. Our systematic review protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews) under registration number CRD42023456009. Results: A total of 9 observational studies involving 990 patients from three countries (USA, Netherlands, and Germany) were included in our study. Pooled results show that the risk of the OviTex group was lower than that of the comparison group (pooled risk ratio (RR) = 0.84; 95% confidence interval (CI): 0.67-1.05; Z = -1.514; p = 0.13). The prevalence rate of primary abdominal wall hernia among the included studies ranged from a minimum of 43% (95% CI: 30-58) to a maximum of 81% (95% CI: 64-91%), the risk was not significantly higher in the comparison group compared with the OviTex group (pooled RR = 1.11; 95% CI: 0.29-4.30; Z = 0.155; p = 0.877), the prevalence of laparoscopic surgery was 12% (95% CI: 6-19%), the BMI was favorable in the comparison group but was not statistically significant (mean difference = 25; 95% CI: -0.02, 0.52; p = 0.073). Conclusion: OviTex RTM has shown promising outcomes in abdominal wall reconstruction and hernia repair. However, it is crucial to conduct further research and clinical studies to confirm these findings and unlock the capabilities of OviTex across different medical scenarios.

Keywords: Hernia; OviTex; clinical outcomes; repair.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.
PRISMA diagram of the literature search.
Figure 2.
Figure 2.
Forest plot of BMI comparison for hernia treatment.
Figure 3.
Figure 3.
Forest plot of the primary abdominal wall hernia in the OviTex and comparison groups.
Figure 4.
Figure 4.
Forest plot of recurrent hernia in the OviTex and comparison groups.
Figure 5.
Figure 5.
Forest plot of the postoperative risk in the OviTex and comparison groups.
Figure 6.
Figure 6.
Forest plot of the proportion of primary abdominal wall hernia.
Figure 7.
Figure 7.
Forest plot of the proportion of recurrent hernia.
Figure 8.
Figure 8.
Forest plot of open surgery for hernia repair.
Figure 9.
Figure 9.
Forest plot of laparoscopic surgery for hernia repair.
Figure 10.
Figure 10.
Forest plot of the surgical site occurrence for hernia.
Figure 11.
Figure 11.
Forest plot of surgical site infection for hernia.
Figure 12.
Figure 12.
Funnel plot for detecting publication bias.
See this image and copyright information in PMC

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