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. 2024 Apr 10:7:100062.
doi: 10.1016/j.jposna.2024.100062. eCollection 2024 May.

Spine health: Back pain and deformity progression

Chinmay S Paranjape  1 , Michelle C Welborn  1
Affiliations

Spine health: Back pain and deformity progression

Chinmay S Paranjape et al. J Pediatr Soc North Am. .

Erratum in

Abstract

Back pain and spinal deformity arising from a variety of etiologies are closely linked to alterations in bone health. This review is intended to summarize the known processes for each of these conditions that negatively impact bone health. It will then elucidate how poor bone quality can further worsen deformity. Finally, it will discuss how interventions targeting improvement in bone health may affect treatment and progression of deformity.

Key concepts: (1)Back pain is highly prevalent affecting up to a third of adolescents and is even more so in patients who are vitamin D deficient.(2)Scoliosis patients from various etiologies all experience higher rates of back pain and tend to have lower bone mineral density than their healthy pediatric peers.(3)There is an interplay between deformity and bone health, where deformity can both drive and be driven by bone health.(4)Treatments targeting bone health may positively affect both natural history and surgical outcomes for patients who have scoliosis with various underlying etiologies.(5)Further research is needed to elucidate mechanistic pathways that link bone health to deformity and to evaluate targets for therapy.

Keywords: Bone health; Osteogenesis imperfecta; Pain; Scoliosis; Spine; Spondylolisthesis.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Chinmay Paranjape reports a relationship with Stryker that includes equity or stocks. Chinmay Paranjape reports a relationship with OrthoPediatrics that includes equity or stocks. Chinmay Paranjape reports a relationship with ATEC Spine, Inc. that includes equity or stocks. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Lumbar spondylolysis. Lumbar spondylolysis with very mild translation of L5 forward on S1, indicating slight anterolisthesis. Note the well corticated margins surrounding the pars fracture, indicating prolonged chronicity. The patient described several bouts of pain followed by relief with rest without any singular inciting trauma.
Figure 2
Figure 2
Progression of scoliosis in type III OI patient with subsequent posterior instrumentation and fusion. OI, Osteogenesis imperfecta.
See this image and copyright information in PMC

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