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Case Reports
. 2025 May 26:18:11795476251345877.
doi: 10.1177/11795476251345877. eCollection 2025.

Reversal of Chorea Hyperglycemia Basal Ganglia Syndrome With Glycemic Control: A Case Report

Sumanth Gundraju  1   2 , Jaideep Menda  3 , Tarun Kumar Suvvari  1   2 , Anupama Kumudavalli Pindi  1   2 , Prudhvi Kumar Davala  1   2 , Tejinder Singh  4 , Vimal Thomas  2   5
Affiliations
Case Reports

Reversal of Chorea Hyperglycemia Basal Ganglia Syndrome With Glycemic Control: A Case Report

Sumanth Gundraju et al. Clin Med Insights Case Rep. .

Abstract

Chorea Hyperglycemia Basal Ganglia Syndrome (CHBG) is an uncommon neurological complication arising in diabetic patients with severe, non-ketotic hyperglycemia. This case report describes a 50-year-old woman presenting with new-onset, choreiform movements in her extremities. Initial workup revealed uncontrolled diabetes (plasma glucose 410 mg/dl, HbA1c 11.2%) with negative serum ketones. Brain MRI findings supported the diagnosis, demonstrating characteristic T1 hyperintensity in the right basal ganglia. Implementation of gradual glycemic control over 48 hours led to significant improvement of her symptoms. This case emphasizes the importance of considering CHBG in the differential diagnosis of movement disorders in patients with uncontrolled diabetes. Early recognition and prompt glycemic management can lead to complete resolution of symptoms, highlighting the crucial role of maintaining proper blood sugar control in diabetic patients.

Keywords: CHBG; Chorea Hyperglycemia Basal Ganglia Syndrome; case report; diabetes mellitus; diabetic striatopathy.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
MRI brain showed T1 hyperintensity in the head of right caudate and putamen nucleus.
See this image and copyright information in PMC

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