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Review
. 2025 May 28.
doi: 10.1002/jcu.24085. Online ahead of print.

Endometrial Osseous Metaplasia: A Retrospective Analysis and Systematic Review

Olimpia Gabrielli  1   2 , Giuliana Orlandi  1   2 , Paolo Toscano  1   2 , Enrica Di Lella  1   2 , Antonia Lettieri  2 , Luigi Manzo  1   2 , Laura Letizia Mazzarelli  1   2 , Gabriele Ruffo  2 , Carmine Sica  2 , Ferdinando Antonio Gulino  3 , Giosuè Giordano Incognito  4 , Attilio Tuscano  4 , Laura Ieno  3 , Marco Palumbo  4 , Maurizio Guida  1 , Aniello Di Meglio  2
Affiliations
Review

Endometrial Osseous Metaplasia: A Retrospective Analysis and Systematic Review

Olimpia Gabrielli et al. J Clin Ultrasound. .

Abstract

Endometrial osseous metaplasia is a rare condition defined as the presence of heterotopic bone in the endometrium. A retrospective, monocentric analysis was conducted, including patients with endometrial osseous metaplasia, and a systematic review of the literature was performed. The retrospective analysis included 10 cases. Most patients (n = 9) were of reproductive age and had a history of miscarriage. The main symptoms were infertility (n = 4) and menstrual cycle disorders (n = 4). The size and the uterine site of the metaplasia varied. It is crucial not to underestimate it, especially in infertile patients with anamnesis of recurrent miscarriages.

Keywords: abortion; bone; endometrium; hysteroscopy; infertility; metaplasia; ultrasound.

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References

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