Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network

Marta De Felice^{1

2}, Hanna J Szkudlarek^{1

2}, Matthew J Jones^{1

2}, Taygun C Uzuneser^{1

2}, Mohammed H Sarikahya^{1

2}, Shawn N Whitehead², Walter J Rushlow^{1

2

3}, Steven R Laviolette^{4

5

6

7

8

9}

Affiliations

¹ Addiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada.
² Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada.
³ Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6 A 3 K7, Canada.
⁴ Addiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.
⁵ Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.
⁶ Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.
⁷ Lawson Health Research Institute, London, ON, N6 C 2R5, Canada. steven.laviolette@schulich.uwo.ca.
⁸ Division of Maternal, Fetal and Newborn Health, Children's Health Research Institute (CHRI), London, ON, N6 C 2R5, Canada. steven.laviolette@schulich.uwo.ca.
⁹ Department of Anatomy & Cell Biology, University of Western Ontario, 468 Medical Science Building, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.

PMID: 40434481
DOI: 10.1007/s00213-025-06817-8

Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network

Marta De Felice et al. Psychopharmacology (Berl). 2025.

. 2025 May 28.

doi: 10.1007/s00213-025-06817-8. Online ahead of print.

Authors

Affiliations

¹ Addiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada.
² Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada.
³ Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6 A 3 K7, Canada.
⁴ Addiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.
⁵ Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.
⁶ Department of Psychiatry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.
⁷ Lawson Health Research Institute, London, ON, N6 C 2R5, Canada. steven.laviolette@schulich.uwo.ca.
⁸ Division of Maternal, Fetal and Newborn Health, Children's Health Research Institute (CHRI), London, ON, N6 C 2R5, Canada. steven.laviolette@schulich.uwo.ca.
⁹ Department of Anatomy & Cell Biology, University of Western Ontario, 468 Medical Science Building, London, ON, N6 A 3 K7, Canada. steven.laviolette@schulich.uwo.ca.

PMID: 40434481
DOI: 10.1007/s00213-025-06817-8

No abstract available

Keywords: Adolescence; Anxiety; Females; Hippocampus; Hypothalamus; Memory; Neurodevelopment; Sensorimotor gating; THC.

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Conflict of interest statement

Declarations. Ethical approval: All experimental procedures and protocols were approved by the appropriate Governmental and Institutional Animal Care and Experimental guidelines at the University of Western Ontario. Competing interests: The authors declare that they have no competing interests related to the content of this manuscript.

References

1. Adam CD, Mirzakhalili E, Gagnon KG, Cottone C, Arena JD, Ulyanova AV, Johnson VE, Wolf JA (2024) Disrupted hippocampal theta-gamma coupling and spike-field coherence following experimental traumatic brain injury. bioRxiv [Preprint]. https://doi.org/10.1101/2024.05.30.596704
1. Amantea D, Spagnuolo P, Bari M et al (2007) Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17β-estradiol. FEBS J 274:4464–4775. https://doi.org/10.1111/j.1742-4658.2007.05975.x - DOI - PubMed
1. Bean LA, Ianov L, Foster TC (2014) Estrogen receptors, the hippocampus, and memory. Neuroscientist 20:534–545. https://doi.org/10.1177/1073858413519865 - DOI - PubMed - PMC
1. Bikbaev A, Manahan-Vaughan D (2009) Relationship of hippocampal theta and gamma oscillations to potentiation of synaptic transmission. Front Neurosci 2:56–63. https://doi.org/10.3389/neuro.01.010.2008 - DOI
1. Brann DW, Dhandapani K, Wakade C et al (2007) Neurotrophic and neuroprotective actions of Estrogen: basic mechanisms and clinical implications. Steroids 72:381–405. https://doi.org/10.1016/j.steroids.2007.02.003 - DOI - PubMed - PMC

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Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network

Affiliations

Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources