Timing is everything - early diagnosis of congenital hypogonadotropic hypogonadism

Jorma Toppari^{1

2}, Taneli Raivio^{3

4}, Sasha R Howard^{5

6}

Affiliations

¹ Research Centre for Integrated Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, and InFLAMES Reseach Flagship Centre, University of Turku, 20520 Turku, Finland.
² Department of Pediatrics, Turku University Hospital, 20520 Turku, Finland.
³ Pediatric Research Center, New Children's Hospital, Helsinki University Hospital, 00290 Helsinki, Finland.
⁴ Stem Cells and Metabolism Research Program (STEMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
⁵ Queen Mary University of London, EC1M 6BQ, London, UK.
⁶ Barts Health NHS Trust, London, E1 1BB, London UK.

Editorial

Jorma Toppari et al. J Clin Endocrinol Metab. 2025.

. 2025 May 28:dgaf320.

doi: 10.1210/clinem/dgaf320. Online ahead of print.

Jorma Toppari^{1

2}, Taneli Raivio^{3

4}, Sasha R Howard^{5

6}

¹ Research Centre for Integrated Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, and InFLAMES Reseach Flagship Centre, University of Turku, 20520 Turku, Finland.
² Department of Pediatrics, Turku University Hospital, 20520 Turku, Finland.
³ Pediatric Research Center, New Children's Hospital, Helsinki University Hospital, 00290 Helsinki, Finland.
⁴ Stem Cells and Metabolism Research Program (STEMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
⁵ Queen Mary University of London, EC1M 6BQ, London, UK.
⁶ Barts Health NHS Trust, London, E1 1BB, London UK.

No abstract available

Keywords: anti-Müllerian hormone; gonadotropin; inhibin B; mini-puberty; pituitary; testosterone.

Comment on

Inhibin B and AMH for Diagnosis of Hypogonadotropic Hypogonadism in Boys Under 1 Year of Age: A Case-control Study.
Gueguen T, Martinerie L, Castets S, Menut V, Villanueva C, Lambert AS, Perge K, Bouhours-Nouet N, Levaillant L, Avril T, Simon D, de Kerdanet M, Lahlou N, Baron S, Reynaud R, Nicolino M, Bouvattier C, Coutant R. Gueguen T, et al. J Clin Endocrinol Metab. 2025 Nov 18;110(12):e4119-e4128. doi: 10.1210/clinem/dgaf219. J Clin Endocrinol Metab. 2025. PMID: 40193582 Free PMC article.