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Review
. 2025 Aug 1;39(15-16):948-974.
doi: 10.1101/gad.352644.125.

Aging and immunity: the age-old tango

Inés Fernández Maestre  1 , Alexander S Harris  1 , Corina Amor  2
Affiliations
Review

Aging and immunity: the age-old tango

Inés Fernández Maestre et al. Genes Dev. .

Abstract

The rising global demographic aging and the subsequent increase in the prevalence of age-related diseases highlight the need to understand aging biology. A key player in organismal aging is the immune system, which has broad systemic effects. On the one hand, immune aging involves the decline of hematopoietic stem cells and significant alterations in the functionality and composition of both innate and adaptive immunity. On the other hand, the aged immune system contributes to chronic inflammation and disrupted tissue homeostasis, thereby driving systemic aging processes. In this review, we examine the close interaction between aging and the immune system and discuss emerging therapeutic strategies aimed at modulating immune function to mitigate age-related pathologies.

Keywords: aging; immunosenescence; senotherapeutics.

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References

    1. Abdullahi A, Knuth CM, Auger C, Sivayoganathan T, Parousis A, Jeschke MG. 2021. Adipose browning response to burn trauma is impaired with aging. JCI Insight 6: e143451. 10.1172/jci.insight.143451 - DOI - PMC - PubMed
    1. Adelman ER, Figueroa ME. 2021. Human hematopoiesis: aging and leukemogenic risk. Curr Opin Hematol 28: 57–63. 10.1097/MOH.0000000000000622 - DOI - PMC - PubMed
    1. Adelman ER, Huang HT, Roisman A, Olsson A, Colaprico A, Qin T, Lindsley RC, Bejar R, Salomonis N, Grimes HL, et al. 2019. Aging human hematopoietic stem cells manifest profound epigenetic reprogramming of enhancers that may predispose to leukemia. Cancer Discov 9: 1080–1101. 10.1158/2159-8290.CD-18-1474 - DOI - PMC - PubMed
    1. Adrover JM, Nicolás-Ávila JA, Hidalgo A. 2016. Aging: a temporal dimension for neutrophils. Trends Immunol 37: 334–345. 10.1016/j.it.2016.03.005 - DOI - PubMed
    1. Ahadi S, Zhou W, Schüssler-Fiorenza Rose SM, Sailani MR, Contrepois K, Avina M, Ashland M, Brunet A, Snyder M. 2020. Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nat Med 26: 83–90. 10.1038/s41591-019-0719-5 - DOI - PMC - PubMed

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