Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 28;41(3):e70100.
doi: 10.1002/joa3.70100. eCollection 2025 Jun.

Opening the door to a new era: A dual-chamber leadless pacemaker

Miyo Nakano  1 , Yusuke Kondo  1 , Richard H Hongo  2 , Hiroyuki Takaoka  1 , Yoshio Kobayashi  1
Affiliations

Opening the door to a new era: A dual-chamber leadless pacemaker

Miyo Nakano et al. J Arrhythm. .

Abstract

Dual-chamber leadless pacing with Aveir DR offers a breakthrough alternative for patients at high risk of infection or with limited vascular access. By enabling both atrial and ventricular pacing without transvenous leads, this technology improves AV synchrony and may revolutionize future cardiac rhythm management, including defibrillation and resynchronization therapies.

Keywords: Aveir; dual‐chamber; leadless pacemaker.

PubMed Disclaimer

Conflict of interest statement

Dr. Kondo received lecture fees from Daiichi‐Sankyo, Abbott Medical Japan, Biotronik Japan, Boston Scientific, Japan Lifeline, Medtronic, and research funds from Daiichi‐Sankyo and Boston Scientific. Dr. Nakano belongs to the endowed department from Abbott Medical Japan, Biotronik Japan, and Fukuda Denshi. Dr. Kobayashi received lecture fees from Abbott Medical Japan, Bayer Japan, Bristol‐Myers Squibb, Boehringer Ingelheim, Daiichi‐Sankyo, and scholarship funds from Takeda Pharmaceutical, Abbott Medical Japan, Terumo, Otsuka Pharmaceutical, Boehringer Ingelheim, Astellas, Daiichi‐Sankyo, Win International, Japan Lifeline, and Nipro.

Figures

FIGURE 1
FIGURE 1
(A) Two‐view chest x‐ray of dual‐chamber leadless pacemaker. (B) Fluoroscopy image confirming successful implantation of Aveir AR and DR devices. (C) Intracardiac electrograms from the Aveir DR system showing appropriate sensing and pacing function. (D) Computed tomography image showing correct device positioning.
See this image and copyright information in PMC

References

    1. Soejima K, Asano T, Ishikawa T, Kusano K, Sato T, Okamura H, et al. Performance of leadless pacemaker in Japanese patients vs. rest of the world ― results from a global clinical trial ―. Circ J. 2017;81:1589–1595. - PubMed
    1. Iwasaki Y, Noda T, Akao M, Fujino T, Hirano T, Inoue K, et al. Guideline focused update on Management of Cardiac Arrhythmias. Circ J. 2024:CJ‐24‐0073. 10.1253/circj.CJ-24-0073 - DOI - PubMed
    1. Knops R, Reddy V, Ip J, Doshi R, Exner D, Defaye P, et al. A dual‐chamber leadless pacemaker. N Engl J Med. 2023;388:2360–2370. - PubMed