Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Apr 30;13(2):12.
doi: 10.21037/atm-25-33. Epub 2025 Apr 29.

Early restrictive versus liberal oxygen for trauma patients: does it make a difference?

Colin F Mackenzie  1
Affiliations
Editorial

Early restrictive versus liberal oxygen for trauma patients: does it make a difference?

Colin F Mackenzie. Ann Transl Med. .
No abstract available

Keywords: 30-day mortality and respiratory complications; Restrictive versus liberal oxygen therapy; oxygen transport after trauma.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-25-33/coif). The author has no conflicts of interest to declare.

Comment on

  • Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial.
    Arleth T, Baekgaard J, Siersma V, Creutzburg A, Dinesen F, Rosenkrantz O, Heiberg J, Isbye D, Mikkelsen S, Hansen PM, Zwisler ST, Darling S, Petersen LB, Mørkeberg MCR, Andersen M, Fenger-Eriksen C, Bach PT, Van Vledder MG, Van Lieshout EMM, Ottenhof NA, Maissan IM, Den Hartog D, Hautz WE, Jakob DA, Iten M, Haenggi M, Albrecht R, Hinkelbein J, Klimek M, Rasmussen LS, Steinmetz J; TRAUMOX2 Trial Group. Arleth T, et al. JAMA. 2025 Feb 11;333(6):479-489. doi: 10.1001/jama.2024.25786. JAMA. 2025. PMID: 39657224 Free PMC article. Clinical Trial.

References

    1. Arleth T, Baekgaard J, Siersma V, et al. Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial. JAMA 2025;333:479-89. 10.1001/jama.2024.25786 - DOI - PMC - PubMed
    1. Young PJ, Arabi YM, Bagshaw SM, et al. Protocol and statistical analysis plan for the mega randomised registry trial research program comparing conservative versus liberal oxygenation targets in adults receiving unplanned invasive mechanical ventilation in the ICU (Mega-ROX). Crit Care Resusc 2022;24:137-49. 10.51893/2022.2.OA4 - DOI - PMC - PubMed

LinkOut - more resources