Promising results with the daily oral small molecule lipoprotein(a) inhibitor, muvalaplin, in high-risk cardiovascular patients with elevated lipoprotein(a) levels
- PMID: 40438517
- PMCID: PMC12106114
- DOI: 10.21037/atm-25-40
Promising results with the daily oral small molecule lipoprotein(a) inhibitor, muvalaplin, in high-risk cardiovascular patients with elevated lipoprotein(a) levels
Keywords: Lipoprotein(a) [Lp(a)]; atherosclerotic cardiovascular disease (ASCVD); low-density lipoprotein cholesterol (LDL-C); muvalaplin; small molecule Lp(a) inhibitors.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-25-40/coif). A.V. has received consultancy fees from Amgen and Novartis. P.T.K. has received consultancy fees, lecture honoraria, and/or travel fees from Amgen, Novartis, Raisio Group, Amarin and Sanofi. F.R. has received research grants, honoraria, or consulting fees for professional input and/or lectures from Sanofi, Regeneron, Amgen, Novartis and LIB Therapeutics. The authors have no other conflicts of interest to declare.
Comment on
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Oral Muvalaplin for Lowering of Lipoprotein(a): A Randomized Clinical Trial.JAMA. 2025 Jan 21;333(3):222-231. doi: 10.1001/jama.2024.24017. JAMA. 2025. PMID: 39556768 Free PMC article. Clinical Trial.
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