doi: 10.3324/haematol.2024.287136.
Online ahead of print.
T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines
Cilia R Pothast
1
, Quincy Hofsink
2
, Sabine Haggenburg
2
, Romy C Dijkland
1
, Marian Van de Meent
1
, Kayleigh Van Dijk
1
, Michel S Bhoekhan
2
, Nienke J E Haverkate
3
, Johan Van Meerloo
4
, J H Frederik Falkenburg
1
, Ruben A L De Groen
1
, Annoek E C Broers
5
, Jaap A Van Doesum
6
, Rob S Van Binnendijk
7
, Gerco Den Hartog
8
, Birgit I Lissenberg-Witte
9
, Arnon P Kater
10
, Gaby P Smits
8
, Dorine Wouters
11
, Ester M M Van Leeuwen
12
, Hetty J Bontkes
13
, Neeltje A Kootstra
3
, Sandra Vogels-Nooijen
14
, Debbie Van Baarle
15
, Rory D De Vries
16
, Tom Van Meerten
6
, Pim G N J Mutsaers
5
, Abraham Goorhuis
17
, Inger S Nijhof
18
, Mette D Hazenberg
19
, Mirjam H M Heemskerk
1
, Caroline E Rutten
20
; COBRA KAI study team
Collaborators,
Affiliations
Collaborators
-
COBRA KAI study team:
Iris Kant, Thecla Graas, Belle Toussaint, Sterre de Jong, Shahan Darwesh, Sandjiv Mahes, Dora Kamminga, Koelewijn Matthijs, Gino Faber, Guus Beaumont, Marije Engel, Cheyenne R Pierie, Suzanne Janssen, Kazimierz Groen, Judith Burger, Joey Bouhuijs, Paul Baars, Marit van Gils, Edith van Dijkman, Jarom Heijmans, Yara Witte, Rogers Nahui Palomino, Said Omar, Sonja Zweegman, Caya van den Vegt, Ilonka Arends-Halbesma, Emma de Pater, Margriet Dijkstra, Nynke Rots, Esther Siteur-van Rijnstra, Dennis de Rooij, Rogier Sanders, Meliawati Poniman, Wouter Olijhoek, Jacqueline van Rijswijk, Tim Beaumont, Lusia Çetinel, Louis Schellekens, Yvonne den Hartogh, Jacqueline Cloos, Suzanne Weijers, Saïda Tonouh-Aajoud, Selime Avci, Elianne Roelandse-Koop, Willem Dik
Affiliations
- 1 Department of Hematology, Leiden UMC, Leiden.
- 2 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam.
- 3 Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam.
- 4 Department of Hematology, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam.
- 5 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam.
- 6 Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen.
- 7 Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Nijmegen.
- 8 Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven.
- 9 Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit, Amsterdam.
- 10 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam.
- 11 Department of Laboratory Medicine, Central Diagnostic Laboratory, Amsterdam UMC, Amsterdam.
- 12 Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Department of Laboratory Medicine, Laboratory for Specialized Diagnostics and Research, Laboratory Medical Immunology, Amsterdam UMC, Amsterdam.
- 13 Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Department of Laboratory Medicine, Laboratory for Specialized Diagnostics and Research, Laboratory Medical Immunology, Amsterdam UMC, Amsterdam.
- 14 Netherlands Comprehensive Cancer Organisation, Utrecht.
- 15 Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen.
- 16 Department of Viroscience, Erasmus University Medical Center, Rotterdam.
- 17 Department of Infectious Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam.
- 18 Department of Hematology, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Internal Medicine-Hematology, St. Antonius Hospital, Nieuwegein.
- 19 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Hematopoiesis, Sanquin Research, Amsterdam.
- 20 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam. c.e.rutten@amsterdamumc.nl.
- PMID: 40438989
- DOI: 10.3324/haematol.2024.287136
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T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines
Cilia R Pothast et al.
Haematologica.
.
Free article
Display options
Format
doi: 10.3324/haematol.2024.287136.
Online ahead of print.
Authors
Cilia R Pothast
1
, Quincy Hofsink
2
, Sabine Haggenburg
2
, Romy C Dijkland
1
, Marian Van de Meent
1
, Kayleigh Van Dijk
1
, Michel S Bhoekhan
2
, Nienke J E Haverkate
3
, Johan Van Meerloo
4
, J H Frederik Falkenburg
1
, Ruben A L De Groen
1
, Annoek E C Broers
5
, Jaap A Van Doesum
6
, Rob S Van Binnendijk
7
, Gerco Den Hartog
8
, Birgit I Lissenberg-Witte
9
, Arnon P Kater
10
, Gaby P Smits
8
, Dorine Wouters
11
, Ester M M Van Leeuwen
12
, Hetty J Bontkes
13
, Neeltje A Kootstra
3
, Sandra Vogels-Nooijen
14
, Debbie Van Baarle
15
, Rory D De Vries
16
, Tom Van Meerten
6
, Pim G N J Mutsaers
5
, Abraham Goorhuis
17
, Inger S Nijhof
18
, Mette D Hazenberg
19
, Mirjam H M Heemskerk
1
, Caroline E Rutten
20
; COBRA KAI study team
Collaborators
-
COBRA KAI study team:
Iris Kant, Thecla Graas, Belle Toussaint, Sterre de Jong, Shahan Darwesh, Sandjiv Mahes, Dora Kamminga, Koelewijn Matthijs, Gino Faber, Guus Beaumont, Marije Engel, Cheyenne R Pierie, Suzanne Janssen, Kazimierz Groen, Judith Burger, Joey Bouhuijs, Paul Baars, Marit van Gils, Edith van Dijkman, Jarom Heijmans, Yara Witte, Rogers Nahui Palomino, Said Omar, Sonja Zweegman, Caya van den Vegt, Ilonka Arends-Halbesma, Emma de Pater, Margriet Dijkstra, Nynke Rots, Esther Siteur-van Rijnstra, Dennis de Rooij, Rogier Sanders, Meliawati Poniman, Wouter Olijhoek, Jacqueline van Rijswijk, Tim Beaumont, Lusia Çetinel, Louis Schellekens, Yvonne den Hartogh, Jacqueline Cloos, Suzanne Weijers, Saïda Tonouh-Aajoud, Selime Avci, Elianne Roelandse-Koop, Willem Dik
Affiliations
- 1 Department of Hematology, Leiden UMC, Leiden.
- 2 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam.
- 3 Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam.
- 4 Department of Hematology, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam.
- 5 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam.
- 6 Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen.
- 7 Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Nijmegen.
- 8 Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven.
- 9 Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit, Amsterdam.
- 10 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam.
- 11 Department of Laboratory Medicine, Central Diagnostic Laboratory, Amsterdam UMC, Amsterdam.
- 12 Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Department of Laboratory Medicine, Laboratory for Specialized Diagnostics and Research, Laboratory Medical Immunology, Amsterdam UMC, Amsterdam.
- 13 Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Department of Laboratory Medicine, Laboratory for Specialized Diagnostics and Research, Laboratory Medical Immunology, Amsterdam UMC, Amsterdam.
- 14 Netherlands Comprehensive Cancer Organisation, Utrecht.
- 15 Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen.
- 16 Department of Viroscience, Erasmus University Medical Center, Rotterdam.
- 17 Department of Infectious Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam.
- 18 Department of Hematology, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Internal Medicine-Hematology, St. Antonius Hospital, Nieuwegein.
- 19 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Hematopoiesis, Sanquin Research, Amsterdam.
- 20 Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam. c.e.rutten@amsterdamumc.nl.
- PMID: 40438989
- DOI: 10.3324/haematol.2024.287136
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