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. 1985;12(2):125-31.
doi: 10.1016/0047-0740(85)90167-6.

Protein-binding and urinary excretion of 99mTc(Sn)-MDP and 99mTc-MDP

T J Savelkoul, J J van Ginkel, R J Grouls, S J Oldenburg, S A Duursma

Protein-binding and urinary excretion of 99mTc(Sn)-MDP and 99mTc-MDP

T J Savelkoul et al. Int J Nucl Med Biol. 1985.

Abstract

In an incubation experiment the Human Serum Albumin (HSA) binding of 99mTc-MDP (electrolytically labeled) and 99mTc(Sn)-MDP is established. During the incubation some pertechnetate is formed and in the case of 99mTc(Sn)-MDP also some hydrolyzed 99mTc. The HSA binding of 99mTc-MDP is less than the HSA binding of 99mTc(Sn)-MDP as established with gel chromatography, TCA-precipitation, ammonium sulfate precipitation and ultrafiltration. TCA-precipitation seems to be an insufficient method for determining the protein binding of 99mTc(Sn)-MDP. The urinary excretion in rats shows only one 99mTc-compound in both cases. The bone seeking properties of the urine-excreted 99mTc-compound were confirmed in another rat.

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