Clinical characteristics and outcomes of hospitalized patients with heart failure from the Japanese prospective registry

Nobuyuki Enzan¹, Takeshi Tohyama², Tatsuya Watanabe³, Takuya Nagata³, Eri Noda³, Yoshitomo Tsutsui³, Masataka Ikeda³, Takafumi Sakamoto³, Shouji Matsushima³, Yuya Matsue⁴, Takeshi Kitai⁵, Tatsunori Taniguchi⁶, Keisuke Kida⁷, Takahiro Okumura⁸, Takuya Kishi⁹, Tomomi Ide³, Hiroyuki Tsutsui¹⁰

Affiliations

¹ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA; International University of Health and Welfare, Okawa, Japan.
² Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; International University of Health and Welfare, Okawa, Japan; Center for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
⁴ Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁵ Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
⁶ Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
⁷ Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan.
⁸ Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁹ International University of Health and Welfare, Okawa, Japan.
¹⁰ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; International University of Health and Welfare, Okawa, Japan. Electronic address: tsutsui.hiroyuki.691@m.kyushu-u.ac.jp.

PMID: 40441437
DOI: 10.1016/j.jjcc.2025.05.015

Clinical characteristics and outcomes of hospitalized patients with heart failure from the Japanese prospective registry

Nobuyuki Enzan et al. J Cardiol. 2025.

. 2025 May 27:S0914-5087(25)00139-X.

doi: 10.1016/j.jjcc.2025.05.015. Online ahead of print.

Authors

Affiliations

¹ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA; International University of Health and Welfare, Okawa, Japan.
² Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; International University of Health and Welfare, Okawa, Japan; Center for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
⁴ Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁵ Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
⁶ Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
⁷ Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan.
⁸ Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁹ International University of Health and Welfare, Okawa, Japan.
¹⁰ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; International University of Health and Welfare, Okawa, Japan. Electronic address: tsutsui.hiroyuki.691@m.kyushu-u.ac.jp.

PMID: 40441437
DOI: 10.1016/j.jjcc.2025.05.015

Abstract

Background: Recent studies showed that clinical parameters other than cardiac function, such as physical function, cognitive function, mental status, social status, and quality of life, were associated with heart failure (HF) prognosis. These parameters have not been extensively investigated in large Japanese cohorts. Furthermore, novel biomarkers to predict prognosis or treatment responses are required to provide individualized medicine. To address these issues, we developed the Japanese Registry Of Acute Decompensated Heart Failure (JROADHF-NEXT).

Methods: JROADHF-NEXT is a prospective, multicenter, nationwide registry of patients hospitalized for acute decompensated HF. A total of 4016 patients were enrolled from 87 centers and blood and urine samples were collected from 3203 of these patients. The study protocol using the JROADHF-NEXT database was approved by all Kyushu University, International University of Health and Welfare and participating hospitals.

Results: The mean age was 72.9 ± 14.0 years and 61.4 % were male. Cardiomyopathy was the most common etiology (24.4 %). Volume overload and arrhythmia accounted for 26.3 % and 17.4 % of precipitating causes. The median follow-up period was 2.0 (1.6-2.2) years and 2-year follow-up completion rate was 88.5 % (n = 3554). The incidence rates for cardiovascular death and rehospitalization for HF were 5.2 and 16.7 per 100 person-years, respectively.

Conclusions: The JROADHF-NEXT is a large-scale HF registry comprising extensive clinical variables with a biobank. This registry is anticipated to provide valuable insights and serve as a significant source of evidence for future research and clinical practice.

Keywords: Biobank; Heart failure; Nationwide registry.

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Conflict of interest statement

Declaration of competing interest N.E. was supported by the Uehara Memorial Foundation Fellowship and the Tsuchiya Memorial Foundation Fellowship. T. Tohyama was affiliated with the collaborative research division of Mochida Pharmaceuticals (FY2024; April 1, 2023 – March 31, 2024) and supported by the Cardiovascular Innovative Conference grant and the Uehara Memorial Foundation Fellowship. M.I. received research funding from MEDINET Co. Ltd. M.I. was affiliated with the collaborative research division of MEDINET Co. Ltd. (FY2023; April 1, 2022 – March 31, 2023). T.S. reports lecture fees from Astellas Pharma Inc., Ono Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Co., Boehringer Ingelheim, Novartis Pharma K.K., Bristol-Myers Squibb Company, Daiichi Sankyo Co., Ltd., Bayer Inc., Medtronic, Abbott, and Edwards Lifesciences Corporation. S.M. reports grants from Astellas Pharma and Tsumura Corporation, outside the submitted work. Y.M. received honoraria from Otsuka Pharmaceutical Co., EN Otsuka Pharmaceutical CO., Novartis Pharma K.K., Bayer Inc., Pfizer Japan Inc., Nippon Boehringer Ingelheim Co., and AstraZeneca, and a collaborative research grant from Pfizer Japan Inc., Otsuka Pharmaceutical Co., EN Otsuka Pharmaceutical Co., Ltd., Roch Diagnostics K.K., and Nippon Boehringer Ingelheim Co., Ltd. T. Kitai received honoraria from AstraZeneca, Alnylam Japan, Bayer Inc., Ono Pharmaceutical Co., Otsuka Pharmaceutical Co., EN Otsuka Pharmaceutical CO., Novartis Pharma K.K., Nippon Boehringer Ingelheim Co., and Pfizer Japan Inc. T. Taniguchi is the founder and a shareholder of Remohab Inc. K.K. received honoraria from AstraZeneca K.K., Ono Pharmaceutical Co., Ltd., Nippon Boehringer Ingelheim Co., Ltd., Bayer Yakuhin, Ltd., Otsuka Pharmaceutical Co., Ltd., and Novartis Pharmaceuticals Co., Ltd. T.O. received honoraria from AstraZeneca, Pfizer, Boehringer Ingelheim, Novartis, Otsuka, and Ono Yakuhin and research grants from Pfizer, Alnylam, Alexion, and Ono Yakuhin. T. Kishi received honoraria from Otsuka Pharmaceutical Co., Novartis Pharma K.K., Bayer Inc., Nippon Boehringer Ingelheim Co., Ltd., Astellas Pharma, Inc., Daiichi Sankyo Co., Ltd., and AstraZeneca. H.T. reports receiving consultancy fees from Nippon Boehringer Ingelheim Co., Ltd., Bayer Yakuhin, Ltd., Novartis Pharma K.K., Ono Pharmaceutical Co., Ltd.; Remuneration from MSD K.K., Astellas Pharma Inc., Pfizer Japan Inc., Bristol-Myers Squibb Company, Otsuka Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Nippon Boehringer Ingelheim Co., Ltd., Takeda Pharmaceutical Company Limited, Bayer Yakuhin, Ltd., Novartis Pharma K.K., Kowa Pharmaceutical Co. Ltd., Teijin Pharma Ltd.; Manuscript fees from Medical View, Nippon Rinsho; Research funding from Actelion Pharmaceuticals Japan Ltd., Mitsubishi Tanabe Pharma Corporation, Nippon Boehringer Ingelheim Co., Ltd., Daiichi Sankyo Co., Ltd., IQVIA Services Japan, Omron Healthcare; scholarship funds from Astellas Pharma Inc., Novartis Pharma K.K., Daiichi Sankyo Co., Ltd., Takeda Pharmaceutical Company Limited, Mitsubishi Tanabe Pharma Corporation, Teijin Pharma Ltd., MSD K.K.

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Clinical characteristics and outcomes of hospitalized patients with heart failure from the Japanese prospective registry

Affiliations

Clinical characteristics and outcomes of hospitalized patients with heart failure from the Japanese prospective registry

Authors

Affiliations

Abstract

Conflict of interest statement

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