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. 2025 Oct 15:387:119541.
doi: 10.1016/j.jad.2025.119541. Epub 2025 May 27.

The interplay among nonsuicidal self-injury, depression, loneliness, resilience, and family relationships in youth: A path analysis

Affiliations

The interplay among nonsuicidal self-injury, depression, loneliness, resilience, and family relationships in youth: A path analysis

Jessica Dagani et al. J Affect Disord. .

Abstract

Background: Recent research has increasingly highlighted the complex interplay among depression, loneliness, and non-suicidal self-injury (NSSI). Resilience and family relationships have emerged as potential protective factors in mitigating these mental health challenges.

Methods: This study investigated the associations among depression, loneliness, NSSI, resilience, and family relationships in a sample of 7146 Italian high school and university students. Participants completed a multidimensional online survey featuring standardized instruments to assess depressive symptoms, loneliness and resilience. Spearman correlations and path analysis were employed to examine the interrelationships among these variables.

Results: A substantial proportion of participants reported clinically significant depressive symptoms (42.8 %) and NSSI behaviours (28.4 %). Path analysis revealed a strong positive effect of depressive symptoms on both loneliness and NSSI, alongside a pronounced negative effect on satisfaction with family relationships and resilience. Loneliness significantly reduced satisfaction with family relationships and resilience, while the impact on NSSI was significant, but minimal. Family relationships exhibited a significant but modest negative effect on NSSI behaviours.

Limitations: The generalizability of the sample and the potential biases inherent in self-report measures are addressed.

Conclusions: This study highlights the intricate interplay between depressive symptoms, loneliness, NSSI, resilience, and family relationships in a large sample of Italian adolescents and young adults. The findings emphasize the need for comprehensive interventions targeting these factors to enhance mental health and well-being.

Keywords: Depression; Loneliness; Mental health; Non-suicidal self-injury; Resilience; Students.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mariangela Lanfredi reports financial support was provided by Italian Ministry of Health. Roberta Rossi reports financial support was provided by Italian Ministry of Health. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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